Molecular biology of the voltage-gated sodium channel

Lawrence Salkoff, Alice Butler, Aguan Wei, Nancy Scavarda, Keith Baker, David Pauron, Cynthia Smith

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

The integral membrane protein composing the voltage-sensitive sodium channel is a bagel-like structure (Fig. 1) with a central pore that is highly selective for sodium ions. When the electric field across a cell's membrane becomes depolarized, the pore of the channel opens to allow sodium ions to flow down their electrochemical gradient into the cell1. Voltage-gating, a common feature of all voltage-activated channels, is an essential functional property that is only now being understood in terms of the structural features of the protein.

Original languageEnglish
Pages (from-to)522-527
Number of pages6
JournalTrends in Neurosciences
Volume10
Issue number12
DOIs
StatePublished - Dec 1987

Fingerprint

Dive into the research topics of 'Molecular biology of the voltage-gated sodium channel'. Together they form a unique fingerprint.

Cite this