Molecular biology of duchenne and Becker's muscular dystrophy: Clinical applications

David H. Gutmann, Kenneth H. Fischbeck

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Recent advances in molecular genetics have led to the isolation of the gene defective in patients with Duchenne and Becker's muscular dystrophy and the characterization of its protein product, dystrophin. In this communication, the developments culminating in the identification of the Duchenne muscular dystrophy locus are reviewed. The practical applications of this research and pitfalls that limit prenatal diagnosis and carrier detection are discussed.

Original languageEnglish
Pages (from-to)189-194
Number of pages6
JournalAnnals of neurology
Volume26
Issue number2
DOIs
StatePublished - Aug 1989

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