Molecular basis of complement deficiencies

D. H. Perlmutter, H. R. Colten

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Genetically determined human complement deficiencies and genetic deficiencies of the corresponding proteins in other species have been recognized for many years. In the past decade, molecular cloning methods have been utilized to deduce the complete primary structure of most of the complement proteins, determine the structure and chromosomal localization of many complement genes, and to define the basis for complement genetic variants including null alleles.

Original languageEnglish
Pages (from-to)105-133
Number of pages29
JournalImmunodeficiency Reviews
Volume1
Issue number2
StatePublished - Jan 1 1989

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