The crystal structure of the AAG/ A-DNA complex is extremely valuable in understanding the substrate specify and mechanism of excision repair by the human alkyladenine glycosylase. However, it is still different cult to obtain a complete picture of the entire functional pathway of the enzyme based solely on the crystal structure. Science should look forward to cocrystalization of the AAG enzyme complexed with other known substrates. This would be of great value in understanding the role of the adduct structure in the mechanism of mammalian DNA repair.
|Number of pages||6|
|State||Published - Jan 1 2001|