Molecular and Genetic Bases for the Circadian System

C. H. Ko; J. S. Takahashi

doi:10.1016/B978-0-12-378610-4.00090-5

Molecular and Genetic Bases for the Circadian System

C. H. Ko, J. S. Takahashi

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

Circadian rhythms represent an evolutionarily conserved adaptation to the environment that can be traced back to the earliest life forms. In animals, circadian behavior can be analyzed as an integrated system beginning with genes and leading ultimately to behavioral outputs. In the last decade, the molecular mechanism of circadian clocks has been uncovered by the use of phenotype-driven (forward) genetic analysis in a number of model systems. Circadian oscillations are generated by a set of genes forming a transcriptional autoregulatory feedback loop. Here, the molecular basis of circadian rhythms and the influence of circadian mutations on sleep are reviewed.

Original language	English
Title of host publication	Encyclopedia of Sleep
Publisher	Elsevier Inc.
Pages	407-412
Number of pages	6
ISBN (Electronic)	9780123786111
ISBN (Print)	9780123786104
DOIs	https://doi.org/10.1016/B978-0-12-378610-4.00090-5
State	Published - Jan 1 2013

Keywords

Biological clock
Bmal1
Casein kinase 1
Circadian rhythms
Clock
Cryptochrome
Npas2
Period
Suprachiasmatic nucleus

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10.1016/B978-0-12-378610-4.00090-5

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AB - Circadian rhythms represent an evolutionarily conserved adaptation to the environment that can be traced back to the earliest life forms. In animals, circadian behavior can be analyzed as an integrated system beginning with genes and leading ultimately to behavioral outputs. In the last decade, the molecular mechanism of circadian clocks has been uncovered by the use of phenotype-driven (forward) genetic analysis in a number of model systems. Circadian oscillations are generated by a set of genes forming a transcriptional autoregulatory feedback loop. Here, the molecular basis of circadian rhythms and the influence of circadian mutations on sleep are reviewed.

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KW - Clock

KW - Cryptochrome

KW - Npas2

KW - Period

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SN - 9780123786104

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EP - 412

BT - Encyclopedia of Sleep

PB - Elsevier Inc.

ER -

Molecular and Genetic Bases for the Circadian System

Abstract

Keywords

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