Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic acid

Maryjo Lechowicz; Dirk P. Dittmer; Jeannette Y. Lee; Susan E. Krown; William Wachsman; David Aboulafia; Bruce J. Dezube; Lee Ratner; Jonathan Said; Richard F. Ambinder

doi:10.1086/648447

Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic acid

Maryjo Lechowicz, Dirk P. Dittmer, Jeannette Y. Lee, Susan E. Krown, William Wachsman, David Aboulafia, Bruce J. Dezube, Lee Ratner, Jonathan Said, Richard F. Ambinder

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy.

Original language	English
Pages (from-to)	1946-1949
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	49
Issue number	12
DOIs	https://doi.org/10.1086/648447
State	Published - Dec 2009

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title = "Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic acid",

abstract = "The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy.",

author = "Maryjo Lechowicz and Dittmer, {Dirk P.} and Lee, {Jeannette Y.} and Krown, {Susan E.} and William Wachsman and David Aboulafia and Dezube, {Bruce J.} and Lee Ratner and Jonathan Said and Ambinder, {Richard F.}",

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AU - Wachsman, William

AU - Aboulafia, David

AU - Dezube, Bruce J.

AU - Ratner, Lee

AU - Said, Jonathan

AU - Ambinder, Richard F.

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AB - The AIDS Malignancy Consortium undertook a pilot trial of valproic acid among patients with AIDS-associated Kaposi sarcoma (KS). Treatment was associated with low toxicity, but the KS clinical response and KS herpesvirus lytic induction rates were not sufficiently high to meet predefined criteria for efficacy.

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Molecular and clinical assessment in the treatment of AIDS Kaposi sarcoma with valproic acid

Abstract

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