Injection of antigen into the anterior chamber (AC) of the eye results in the induction of anterior chamber-associated immune deviation (ACAID). ACAID is characterized by suppressed systemic cell-mediated immunity with normal antibody production. Previous studies have shown that visible light is a critical component to the development of ACAID. In these studies, we have examined the effect of light on ocular and inflammatory cells relevant to HSV-ACAID. Nonadherent, mononuclear cells obtained from the eye of diurnally reared mice 48 hr following AC injection of HSV-1 transfer ACAID to naive recipients. In contrast, mononuclear, nonadherent cell populations from dark- reared mice transfer immunity. Also, mononuclear cells from diurnally reared (HSV-injected) mice produce the soluble, TCR α-chain related ACAID-inducing signal when cultured in vitro, while cells from dark-reared mice do not. These results demonstrate that light/dark has the capacity to modulate the intraocular immune response to antigens presented in the eye.
|Number of pages||5|
|State||Published - Dec 1 1994|