Modulation of the brain's functional network architecture in the transition from wake to sleep

Linda J. Larson-Prior, Jonathan D. Power, Justin L. Vincent, Tracy S. Nolan, Rebecca S. Coalson, John Zempel, Abraham Z. Snyder, Bradley L. Schlaggar, Marcus E. Raichle, Steven E. Petersen

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

90 Scopus citations

Abstract

The transition from quiet wakeful rest to sleep represents a period over which attention to the external environment fades. Neuroimaging methodologies have provided much information on the shift in neural activity patterns in sleep, but the dynamic restructuring of human brain networks in the transitional period from wake to sleep remains poorly understood. Analysis of electrophysiological measures and functional network connectivity of these early transitional states shows subtle shifts in network architecture that are consistent with reduced external attentiveness and increased internal and self-referential processing. Further, descent to sleep is accompanied by the loss of connectivity in anterior and posterior portions of the default-mode network and more locally organized global network architecture. These data clarify the complex and dynamic nature of the transitional period between wake and sleep and suggest the need for more studies investigating the dynamics of these processes.

Original languageEnglish
Title of host publicationProgress in Brain Research
PublisherElsevier B.V.
Pages277-294
Number of pages18
DOIs
StatePublished - 2011

Publication series

NameProgress in Brain Research
Volume193
ISSN (Print)0079-6123
ISSN (Electronic)1875-7855

Keywords

  • Alpha EEG
  • Brain networks
  • EEG/fMRI
  • FMRI
  • Functional connectivity
  • Graph theory
  • Sleep

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