Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase

Dario A. Vitturi; Chen Shan Chen; Steven R. Woodcock; Sonia R. Salvatore; Gustavo Bonacci; Jeffrey R. Koenitzer; Nicolas A. Stewart; Nobunao Wakabayashi; Thomas W. Kensler; Bruce A. Freeman; Francisco J. Schopfer

doi:10.1074/jbc.M113.486282

Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase

Dario A. Vitturi
, Chen Shan Chen
, Steven R. Woodcock
, Sonia R. Salvatore
, Gustavo Bonacci
, Jeffrey R. Koenitzer
, Nicolas A. Stewart
, Nobunao Wakabayashi
, Thomas W. Kensler
, Bruce A. Freeman
, Francisco J. Schopfer

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.

Original language	English
Pages (from-to)	25626-25637
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	288
Issue number	35
DOIs	https://doi.org/10.1074/jbc.M113.486282
State	Published - Aug 30 2013

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Vitturi, D. A., Chen, C. S., Woodcock, S. R., Salvatore, S. R., Bonacci, G., Koenitzer, J. R., Stewart, N. A., Wakabayashi, N., Kensler, T. W., Freeman, B. A., & Schopfer, F. J. (2013). Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase. Journal of Biological Chemistry, 288(35), 25626-25637. https://doi.org/10.1074/jbc.M113.486282

@article{56ce25c66a8a442e9489a13b36f64ecf,

title = "Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase",

abstract = "Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.",

author = "Vitturi, \{Dario A.\} and Chen, \{Chen Shan\} and Woodcock, \{Steven R.\} and Salvatore, \{Sonia R.\} and Gustavo Bonacci and Koenitzer, \{Jeffrey R.\} and Stewart, \{Nicolas A.\} and Nobunao Wakabayashi and Kensler, \{Thomas W.\} and Freeman, \{Bruce A.\} and Schopfer, \{Francisco J.\}",

year = "2013",

month = aug,

day = "30",

doi = "10.1074/jbc.M113.486282",

language = "English",

volume = "288",

pages = "25626--25637",

journal = "Journal of Biological Chemistry",

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TY - JOUR

T1 - Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase

AU - Vitturi, Dario A.

AU - Chen, Chen Shan

AU - Woodcock, Steven R.

AU - Salvatore, Sonia R.

AU - Bonacci, Gustavo

AU - Koenitzer, Jeffrey R.

AU - Stewart, Nicolas A.

AU - Wakabayashi, Nobunao

AU - Kensler, Thomas W.

AU - Freeman, Bruce A.

AU - Schopfer, Francisco J.

PY - 2013/8/30

Y1 - 2013/8/30

N2 - Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.

AB - Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.

UR - https://www.scopus.com/pages/publications/84883352398

U2 - 10.1074/jbc.M113.486282

DO - 10.1074/jbc.M113.486282

M3 - Article

C2 - 23878198

AN - SCOPUS:84883352398

SN - 0021-9258

VL - 288

SP - 25626

EP - 25637

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 35

ER -

Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase

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