TY - JOUR
T1 - Modulation of nitro-fatty acid signaling prostaglandin reductase-1 is a nitroalkene reductase
AU - Vitturi, Dario A.
AU - Chen, Chen Shan
AU - Woodcock, Steven R.
AU - Salvatore, Sonia R.
AU - Bonacci, Gustavo
AU - Koenitzer, Jeffrey R.
AU - Stewart, Nicolas A.
AU - Wakabayashi, Nobunao
AU - Kensler, Thomas W.
AU - Freeman, Bruce A.
AU - Schopfer, Francisco J.
PY - 2013/8/30
Y1 - 2013/8/30
N2 - Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.
AB - Background: Nitroalkenes are electrophilic anti-inflammatory mediators that signal via Michael addition and are metabolized in vivo. Results: Prostaglandin reductase-1 is identified as a nitroalkene reductase. Conclusion: Prostaglandin reductase-1 reduces fatty acid nitroalkenes to nitroalkanes, inactivating electrophilic reactivity. Significance: A mammalian enzyme is identified that metabolizes fatty acid nitroalkenes in vivo to silence their signaling reactions.
UR - http://www.scopus.com/inward/record.url?scp=84883352398&partnerID=8YFLogxK
U2 - 10.1074/jbc.M113.486282
DO - 10.1074/jbc.M113.486282
M3 - Article
C2 - 23878198
AN - SCOPUS:84883352398
SN - 0021-9258
VL - 288
SP - 25626
EP - 25637
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 35
ER -