Modulation of neurofibromatosis type 1 gene expression during in vitro myoblast differentiation

D. H. Gutman; J. L. Cole; F. S. Collins

doi:10.1002/jnr.490370312

Modulation of neurofibromatosis type 1 gene expression during in vitro myoblast differentiation

D. H. Gutman, J. L. Cole, F. S. Collins

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Abstract

Neurofibromin, the protein product of the neurofibromatiosis type 1 NF1 gene, has two alternate isoforms which are generated by alternative splicing of two exons. One of these isoforms containing exon 48a is expressed at highest levels in muscle. Since neurofibromin is a p21‐ras regulator and has been recently shown to be modulated during Schwann cell differentiation, we examined the expression of the NF1 gene product during in vitro muscle differentiation. Previous work demonstrated that C₂

Original language	English
Pages (from-to)	398-405
Number of pages	8
Journal	Journal of Neuroscience Research
Volume	37
Issue number	3
DOIs	https://doi.org/10.1002/jnr.490370312
State	Published - Feb 15 1994

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abstract = "Neurofibromin, the protein product of the neurofibromatiosis type 1 NF1 gene, has two alternate isoforms which are generated by alternative splicing of two exons. One of these isoforms containing exon 48a is expressed at highest levels in muscle. Since neurofibromin is a p21‐ras regulator and has been recently shown to be modulated during Schwann cell differentiation, we examined the expression of the NF1 gene product during in vitro muscle differentiation. Previous work demonstrated that C2",

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AB - Neurofibromin, the protein product of the neurofibromatiosis type 1 NF1 gene, has two alternate isoforms which are generated by alternative splicing of two exons. One of these isoforms containing exon 48a is expressed at highest levels in muscle. Since neurofibromin is a p21‐ras regulator and has been recently shown to be modulated during Schwann cell differentiation, we examined the expression of the NF1 gene product during in vitro muscle differentiation. Previous work demonstrated that C2

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Modulation of neurofibromatosis type 1 gene expression during in vitro myoblast differentiation

Abstract

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