Modulation of neurofibromatosis type 1 gene expression during in vitro myoblast differentiation

D. H. Gutman, J. L. Cole, F. S. Collins

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Neurofibromin, the protein product of the neurofibromatiosis type 1 NF1 gene, has two alternate isoforms which are generated by alternative splicing of two exons. One of these isoforms containing exon 48a is expressed at highest levels in muscle. Since neurofibromin is a p21‐ras regulator and has been recently shown to be modulated during Schwann cell differentiation, we examined the expression of the NF1 gene product during in vitro muscle differentiation. Previous work demonstrated that C2

Original languageEnglish
Pages (from-to)398-405
Number of pages8
JournalJournal of Neuroscience Research
Volume37
Issue number3
DOIs
StatePublished - Feb 15 1994
Externally publishedYes

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