Modulation of mannose and asialoglycoprotein receptor expression determines glycoprotein hormone half-life at critical points in the reproductive cycle

Yiling Mi, Angela Lin, Dorothy Fiete, Lindsay Steirer, Jacques U. Baenziger

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

Background: Unique glycan structures on glycoprotein hormones are recognized by glycan-specific receptors that control hormone half-life in the blood. Results: Clearance rates for recognized glycoproteins are determined by the level of receptor expression in the liver. Conclusion: Expression of glycan-specific receptors is modulated at critical points in the reproductive cycle. Significance: Glycans and glycan-specific receptors play critical roles in reproduction.

Original languageEnglish
Pages (from-to)12157-12167
Number of pages11
JournalJournal of Biological Chemistry
Volume289
Issue number17
DOIs
StatePublished - Apr 25 2014

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