Abstract
Background: Unique glycan structures on glycoprotein hormones are recognized by glycan-specific receptors that control hormone half-life in the blood. Results: Clearance rates for recognized glycoproteins are determined by the level of receptor expression in the liver. Conclusion: Expression of glycan-specific receptors is modulated at critical points in the reproductive cycle. Significance: Glycans and glycan-specific receptors play critical roles in reproduction.
| Original language | English |
|---|---|
| Pages (from-to) | 12157-12167 |
| Number of pages | 11 |
| Journal | Journal of Biological Chemistry |
| Volume | 289 |
| Issue number | 17 |
| DOIs | |
| State | Published - Apr 25 2014 |
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Mi, Y., Lin, A., Fiete, D., Steirer, L., & Baenziger, J. U. (2014). Modulation of mannose and asialoglycoprotein receptor expression determines glycoprotein hormone half-life at critical points in the reproductive cycle. Journal of Biological Chemistry, 289(17), 12157-12167. https://doi.org/10.1074/jbc.M113.544973