Modulation frequency improves imaging hemoglobin fluctuation in frequency domain high-density diffuse optical tomography

Weihao Fan, Hamid Dehghani, Adam T. Eggebrecht

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

We investigated the effects of modulation frequency on image quality with FD-HD-DOT through simulations with a realistic noise model of functional activations in human head models, arising from 11 source modulation frequencies between CW and 1,000 MHz. Functional reconstructions were simulated in five fMRI-based head models covered by 158 light sources and 166 detectors and a realistic noise model was considered. We quantitatively evaluated image quality by assessing the localization error (LE), success rate, full width at half maximum (FWHM), and full volume at half maximum (FVHM) of recoveries. The results show that the optimized frequencies are about 300~500 MHz for image quality and 300 MHz for reliable field of view when accounting for realistic noise.

Original languageEnglish
Title of host publicationClinical and Translational Neurophotonics 2022
EditorsVictor X. D. Yang, Jana M. Kainerstorfer
PublisherSPIE
ISBN (Electronic)9781510647619
DOIs
StatePublished - 2022
EventClinical and Translational Neurophotonics 2022 - Virtual, Online
Duration: Feb 20 2022Feb 24 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume11945
ISSN (Print)1605-7422

Conference

ConferenceClinical and Translational Neurophotonics 2022
CityVirtual, Online
Period02/20/2202/24/22

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