Modulating the voltage sensor of a cardiac potassium channel shows antiarrhythmic effects

Yangyang Lin, Sam Z. Grinter, Zhongju Lu, Xianjin Xu, Hong Zhan Wang, Hongwu Liang, Panpan Hou, Junyuan Gao, Chris Clausen, Jingyi Shi, Wenshan Zhao, Zhiwei Ma, Yongfeng Liu, McFarland White Kelli McFarland White, Lu Zhao, Po Wei Kang, Guohui Zhang, Ira S. Cohen, Xiaoqin Zou, Jianmin Cui

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Cardiac arrhythmias are the most common cause of sudden cardiac death worldwide. Lengthening the ventricular action potential duration (APD), either congenitally or via pathologic or pharmacologic means, predisposes to a life-threatening ventricular arrhythmia, Torsade de Pointes. IKs(KCNQ1+KCNE1), a slowly activating K+ current, plays a role in action potential repolarization. In this study, we screened a chemical library in silico by docking compounds to the voltage-sensing domain (VSD) of the IKschannel. Here, we show that C28 specifically shifted IKsVSD activation in ventricle to more negative voltages and reversed the drug-induced lengthening of APD. At the same dosage, C28 did not cause significant changes of the normal APD in either ventricle or atrium. This study provides evidence in support of a computational prediction of IKsVSD activation as a potential therapeutic approach for all forms of APD prolongation. This outcome could expand the therapeutic efficacy of a myriad of currently approved drugs that may trigger arrhythmias.

Original languageEnglish
Article numbere2024215118
JournalProceedings of the National Academy of Sciences of the United States of America
Volume118
Issue number20
DOIs
StatePublished - May 18 2021

Keywords

  • Antiarrhythmia
  • C28
  • I
  • KCNQ1
  • Voltage sensor domain

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