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Modulating FKBP5/FKBP51 and autophagy lowers HTT (huntingtin) levels
Barbara J. Bailus
, Stephen M. Scheeler
, Jesse Simons
, Maria A. Sanchez
, Kizito Tshitoko Tshilenge
, Jordi Creus-Muncunill
, Swati Naphade
, Alejandro Lopez-Ramirez
, Ningzhe Zhang
, Kuruwitage Lakshika Madushani
, Stanislav Moroz
, Ashley Loureiro
, Katherine H. Schreiber
, Felix Hausch
, Brian K. Kennedy
, Michelle E. Ehrlich
, Lisa M. Ellerby
Department of Biomedical Engineering
Research output
:
Contribution to journal
›
Article
›
peer-review
58
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Scopus citations
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Keyphrases
Autophagy
100%
FKBP51
100%
FKBP5
100%
Mutant Huntingtin (mHTT)
100%
Huntington's Disease
83%
Induced Pluripotent Stem Cells (iPSCs)
25%
Rapamycin
25%
Q175 Mice
25%
Neural Stem Cells
16%
Mouse Model
16%
Actin
16%
ULK1
16%
Isogenic
16%
Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE)
16%
FK506-binding Protein
16%
Co-immunoprecipitation (co-IP)
16%
Pharmacological Inhibitors
16%
Putative Drug Targets
16%
Cell Clearance
16%
Clearance Mechanism
16%
Medium Spiny Neurons
16%
SAFit2
16%
Posttraumatic Stress Disorder
8%
Cortex
8%
Mammalian Target of Rapamycin (mTOR)
8%
Family Members
8%
Parkinson's Disease
8%
Tubulin
8%
Autophagic Flux
8%
SQSTM1
8%
Microtubule-associated Protein 1 Light Chain 3
8%
MAP1LC3B
8%
Protein Family
8%
Small Interfering RNA (siRNA)
8%
Peptidyl-prolyl Cis-trans Isomerase
8%
Striatum
8%
Disease-modifying Therapy
8%
Tris
8%
Genetic Approach
8%
Age-related Illnesses
8%
In Vivo Applications
8%
Autophagic
8%
Bovine Serum Albumin
8%
Neurological Disorders
8%
Immunosuppressive Drugs
8%
Polyglutamine
8%
Pharmacological Approaches
8%
Disease Foci
8%
Protein Phosphatase
8%
Stem Cell Models
8%
Vinculin
8%
Littermate Controls
8%
LC3-II
8%
Microtubule-associated Protein tau
8%
Bafilomycin A1
8%
FKBP12
8%
PPIase
8%
PolyQ
8%
Buffered Saline
8%
Tween
8%
DMSO Dimethyl Sulfoxide
8%
DARPP-32
8%
AD Alzheimer's Disease
8%
Ethanesulfonic Acid
8%
RT Room Temperature
8%
Bicinchoninic Acid
8%
PPP1R1B
8%
BBB Blood-brain Barrier
8%
DTT Dithiothreitol
8%
FKBP1A
8%
Huntington's Disease Models
8%
Sequestosome 1
8%
Mechanistic Target of Rapamycin Kinase
8%
Biochemistry, Genetics and Molecular Biology
Autophagy
100%
Huntingtin
100%
FKBP5
100%
Induced Pluripotent Stem Cell
33%
Stem Cell
33%
Mouse Model
22%
Binding Protein
22%
Polyacrylamide Gel Electrophoresis
22%
Bovine Serum Albumin
22%
Blood Brain Barrier
22%
Medium Spiny Neuron
22%
Genetics
11%
Kinase
11%
Phosphotransferase
11%
Tau
11%
Protein Family
11%
Actin
11%
Synapsin I
11%
Cis-Trans Isomerase
11%
Immunoprecipitation
11%
FKBP
11%
Microtubule-Associated Protein
11%
Protein Phosphatase 1
11%
Light Chain
11%
Tau Protein
11%
Mechanistic Target of Rapamycin
11%
Dithiothreitol
11%
Room Temperature
11%
Tubulin
11%
Vinculin
11%
ULK1
11%
Bafilomycin
11%
Beta-Actin
11%
Dimethyl Sulfoxide
11%
Sequestosome 1
11%
MOPS
11%
PPP1R1B
11%
FKBP1A
11%
Small Interfering RNA
11%