TY - JOUR
T1 - Modularity in the Organization of Mouse Primary Visual Cortex
AU - Ji, Weiqing
AU - Gămănuţ, Răzvan
AU - Bista, Pawan
AU - D'Souza, Rinaldo D.
AU - Wang, Quanxin
AU - Burkhalter, Andreas
N1 - Funding Information:
We thank Paul Foeller, Equan Gao, Justin Horowitz, DoHyun Kim, Blake Mei, Lawrence Tychsen, and Katia Valkova for supplying primate tissue, developing software, and technical support. Supported by National Eye Institute grants RO1 EY016184 (to A.B.), RO1 EY022090 (to A.B.); the McDonnell Center for Systems Neuroscience (to A.B. and R.G.); and Université Lyon I, Fédération des Aveugles de France and LabEx Cortex (ANR-11-LABX-0042) (to R.G.).
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/8/5
Y1 - 2015/8/5
N2 - Layer 1 (L1) of primary visual cortex (V1) is the target of projections from many brain regions outside of V1.We found that inputs to the non-columnar mouse V1 from the dorsal lateral geniculate nucleus and feedback projections from multiple higher cortical areas to L1 are patchy. The patches are matched to a pattern of M2 muscarinic acetylcholine receptor expression at fixed locations of mouse, rat, and monkey V1. Neurons in L2/3 aligned with M2-rich patches have high spatial acuity, whereas cells in M2-poor zones exhibited high temporal acuity. Together M2+ and M2- zones form constant-size domains that are repeated across V1. Domains map subregions of the receptive field, such that multiple copies are contained within the point image. The results suggest that the modular network in mouse V1 selects spatiotemporally distinct clusters of neurons within the point image for top-down control and differential routing of inputs to cortical streams.
AB - Layer 1 (L1) of primary visual cortex (V1) is the target of projections from many brain regions outside of V1.We found that inputs to the non-columnar mouse V1 from the dorsal lateral geniculate nucleus and feedback projections from multiple higher cortical areas to L1 are patchy. The patches are matched to a pattern of M2 muscarinic acetylcholine receptor expression at fixed locations of mouse, rat, and monkey V1. Neurons in L2/3 aligned with M2-rich patches have high spatial acuity, whereas cells in M2-poor zones exhibited high temporal acuity. Together M2+ and M2- zones form constant-size domains that are repeated across V1. Domains map subregions of the receptive field, such that multiple copies are contained within the point image. The results suggest that the modular network in mouse V1 selects spatiotemporally distinct clusters of neurons within the point image for top-down control and differential routing of inputs to cortical streams.
UR - http://www.scopus.com/inward/record.url?scp=84938567780&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2015.07.004
DO - 10.1016/j.neuron.2015.07.004
M3 - Article
C2 - 26247867
AN - SCOPUS:84938567780
SN - 0896-6273
VL - 87
SP - 632
EP - 643
JO - Neuron
JF - Neuron
IS - 3
ER -