TY - JOUR
T1 - Modular network between postrhinal visual cortex, amygdala, and entorhinal cortex
AU - Meier, Andrew M.
AU - Wang, Quanxin
AU - Ji, Weiqing
AU - Ganachaud, Jehan
AU - Burkhalter, Andreas
N1 - Funding Information:
Received Aug. 10, 2020; revised Apr. 2, 2021; accepted Apr. 7, 2021. Author contributions: A.M.M., Q.W., and A.B. designed research; A.M.M., Q.W., W.J., and A.B. performed research; A.M.M., J.G., and A.B. analyzed data; A.M.M. and A.B. wrote the paper. This research was supported by National Eye Institute Grants RO1-EY-016184, RO1-EY-020523, RO1-EY-027383, and R21-EY-027946; and the McDonnell Center for Systems Neuroscience. We thank Katia Valkova for technical support. A. Meier’s present address: Boston University College of Engineering, Boston, MA 02215. Q. Wang’s present address: Allen Institute for Brain Science, Seattle, WA 98109. The authors declare no competing financial interests. Correspondence should be addressed to Andreas Burkhalter at burkhala@wustl.edu. https://doi.org/10.1523/JNEUROSCI.2185-20.2021 Copyright © 2021 the authors
Publisher Copyright:
Copyright © 2021 the authors
PY - 2021/6/2
Y1 - 2021/6/2
N2 - The postrhinal area (POR) is a known center for integrating spatial with nonspatial visual information and a possible hub for influencing landmark navigation by affective input from the amygdala. This may involve specific circuits within muscarinic acetylcholine receptor 2 (M2)-positive (M21) or M2– modules of POR that associate inputs from the thalamus, cortex, and amygdala, and send outputs to the entorhinal cortex. Using anterograde and retrograde labeling with conventional and viral tracers in male and female mice, we found that all higher visual areas of the ventral cortical stream project to the amygdala, while such inputs are absent from primary visual cortex and dorsal stream areas. Unexpectedly for the presumed salt- and-pepper organization of mouse extrastriate cortex, tracing results show that inputs from the dorsal lateral geniculate nucleus and lateral posterior nucleus were spatially clustered in layer 1 (L1) and overlapped with M21 patches of POR. In contrast, input from the amygdala to L1 of POR terminated in M2– interpatches. Importantly, the amygdalocortical input to M2– interpatches in L1 overlapped preferentially with spatially clustered apical dendrites of POR neurons projecting to amygdala and entorhinal area lateral, medial (ENTm). The results suggest that subnetworks in POR, used to build spatial maps for navigation, do not receive direct thalamocortical M21 patch-targeting inputs. Instead, they involve local networks of M2–interpatches, which are influenced by affective information from the amygdala and project to ENTm, whose cells respond to visual landmark cues for navigation.
AB - The postrhinal area (POR) is a known center for integrating spatial with nonspatial visual information and a possible hub for influencing landmark navigation by affective input from the amygdala. This may involve specific circuits within muscarinic acetylcholine receptor 2 (M2)-positive (M21) or M2– modules of POR that associate inputs from the thalamus, cortex, and amygdala, and send outputs to the entorhinal cortex. Using anterograde and retrograde labeling with conventional and viral tracers in male and female mice, we found that all higher visual areas of the ventral cortical stream project to the amygdala, while such inputs are absent from primary visual cortex and dorsal stream areas. Unexpectedly for the presumed salt- and-pepper organization of mouse extrastriate cortex, tracing results show that inputs from the dorsal lateral geniculate nucleus and lateral posterior nucleus were spatially clustered in layer 1 (L1) and overlapped with M21 patches of POR. In contrast, input from the amygdala to L1 of POR terminated in M2– interpatches. Importantly, the amygdalocortical input to M2– interpatches in L1 overlapped preferentially with spatially clustered apical dendrites of POR neurons projecting to amygdala and entorhinal area lateral, medial (ENTm). The results suggest that subnetworks in POR, used to build spatial maps for navigation, do not receive direct thalamocortical M21 patch-targeting inputs. Instead, they involve local networks of M2–interpatches, which are influenced by affective information from the amygdala and project to ENTm, whose cells respond to visual landmark cues for navigation.
KW - Amygdala
KW - Entorhinal cortex
KW - Navigation
KW - Postrhinal cortex
KW - Thalamocortical connections
KW - Visual cortex
UR - http://www.scopus.com/inward/record.url?scp=85107343122&partnerID=8YFLogxK
U2 - 10.1523/JNEUROSCI.2185-20.2021
DO - 10.1523/JNEUROSCI.2185-20.2021
M3 - Article
C2 - 33849948
AN - SCOPUS:85107343122
VL - 41
SP - 4809
EP - 4825
JO - Journal of Neuroscience
JF - Journal of Neuroscience
SN - 0270-6474
IS - 22
ER -