Modifications of Natural Peptides for Nanoparticle and Drug Design

Andrew P. Jallouk, Rohun U. Palekar, Hua Pan, Paul H. Schlesinger, Samuel A. Wickline

Research output: Chapter in Book/Report/Conference proceedingChapter

14 Scopus citations

Abstract

Natural products serve as an important source of novel compounds for drug development. Recently, peptides have emerged as a new class of therapeutic agents due to their versatility and specificity for biological targets. Yet, their effective application often requires use of a nanoparticle delivery system. In this chapter, we review the role of natural peptides in the design and creation of nanomedicines, with a particular focus on cell-penetrating peptides, antimicrobial peptides, and peptide toxins. The use of natural peptides in conjunction with nanoparticle delivery systems holds great promise for the development of new therapeutic formulations as well as novel platforms for the delivery of various cargoes.

Original languageEnglish
Title of host publicationAdvances in Protein Chemistry and Structural Biology
PublisherAcademic Press Inc.
Pages57-91
Number of pages35
DOIs
StatePublished - Jan 1 2015

Publication series

NameAdvances in Protein Chemistry and Structural Biology
Volume98
ISSN (Print)1876-1623

Keywords

  • Antimicrobial peptide
  • Cell-penetrating peptide
  • Drug delivery
  • Nanoparticle
  • Natural peptide
  • Peptide toxin

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    Jallouk, A. P., Palekar, R. U., Pan, H., Schlesinger, P. H., & Wickline, S. A. (2015). Modifications of Natural Peptides for Nanoparticle and Drug Design. In Advances in Protein Chemistry and Structural Biology (pp. 57-91). (Advances in Protein Chemistry and Structural Biology; Vol. 98). Academic Press Inc.. https://doi.org/10.1016/bs.apcsb.2014.12.001