Modification of the oral radiation death syndrome with combined WR-2721 and misonidazole

P. Grigsby, Y. Maruyama

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

In order to investigate the combined use of radioprotective and radiosensitizing chemicals we have used WR-2721 and misonidazole to study their combined chemical toxicity and radiomodifying effects in our model using the oral radiation death (ORD) syndrome as the endpoint. Our data demonstrate that WR-2721 does protect against the ORD syndrome. Misonidazole does not sensitize the normal oral cavity to local irradiation. WR-2721 and misonidazole produce additive toxicity when injected simultaneously and the combination can provide an overall protective response to the ORD syndrome. We conclude that the combination may be potentially useful for the treatment of cancers of the oral cavity.

Original languageEnglish
Pages (from-to)969-972
Number of pages4
JournalBritish Journal of Radiology
Volume54
Issue number647
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

Fingerprint Dive into the research topics of 'Modification of the oral radiation death syndrome with combined WR-2721 and misonidazole'. Together they form a unique fingerprint.

  • Cite this