Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series

Arti Hurria; Christopher R. Carpenter; Frances McFarland; Nancy E. Lundebjerg; Rafael de Cabo; Luigi Ferrucci; Stephanie A. Studenski; Nir Barzilai; Josephine P. Briggs; Joachim H. Ix; Dalane W. Kitzman; George A. Kuchel; Nicolas Musi; John C. Newman; Thomas A. Rando; Alexander K. Smith; Jeremy D. Walston; James L. Kirkland; Raymond Yung

doi:10.1111/jgs.15788

Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series

Arti Hurria, Christopher R. Carpenter, Frances McFarland, Nancy E. Lundebjerg, Rafael de Cabo, Luigi Ferrucci, Stephanie A. Studenski, Nir Barzilai, Josephine P. Briggs, Joachim H. Ix, Dalane W. Kitzman, George A. Kuchel, Nicolas Musi, John C. Newman, Thomas A. Rando, Alexander K. Smith, Jeremy D. Walston, James L. Kirkland, Raymond Yung

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

The American Geriatrics Society convened a conference in Bethesda, Maryland, to explore models and studies of aging. This was the second of three conferences, supported by a U13 grant from the National Institute on Aging, to aid recipients of Grants for Early Medical/Surgical Specialists Transition to Aging Research (GEMSSTAR) in integrating geriatrics into their specialties. Recognizing that aging is the largest risk factor for multiple chronic diseases and age-related loss of resilience, the conference organizers focused scientific sessions on how targeting age-related mechanisms can delay, prevent, or reverse geriatric syndromes, age-related chronic diseases, and loss of resilience. The rationale for studying models of aging as well as study designs, strategies, and challenges of studying human aging were reviewed. This article provides a summary of the full conference report, Models and Studies of Aging: Report from the U13 Conference Series, and summarizes key take-home messages that were designed to support GEMSSTAR awardees in developing their research careers focused on aging research (see supplementary text for the full report). J Am Geriatr Soc 67:428–433, 2019.

Original language	English
Pages (from-to)	428-433
Number of pages	6
Journal	Journal of the American Geriatrics Society
Volume	67
Issue number	3
DOIs	https://doi.org/10.1111/jgs.15788
State	Published - Mar 2019

Keywords

aging
biology
geriatrics
research

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10.1111/jgs.15788

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Hurria, A., Carpenter, C. R., McFarland, F., Lundebjerg, N. E., de Cabo, R., Ferrucci, L., Studenski, S. A., Barzilai, N., Briggs, J. P., Ix, J. H., Kitzman, D. W., Kuchel, G. A., Musi, N., Newman, J. C., Rando, T. A., Smith, A. K., Walston, J. D., Kirkland, J. L., & Yung, R. (2019). Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series. Journal of the American Geriatrics Society, 67(3), 428-433. https://doi.org/10.1111/jgs.15788

Hurria, Arti ; Carpenter, Christopher R. ; McFarland, Frances ; Lundebjerg, Nancy E. ; de Cabo, Rafael ; Ferrucci, Luigi ; Studenski, Stephanie A. ; Barzilai, Nir ; Briggs, Josephine P. ; Ix, Joachim H. ; Kitzman, Dalane W. ; Kuchel, George A. ; Musi, Nicolas ; Newman, John C. ; Rando, Thomas A. ; Smith, Alexander K. ; Walston, Jeremy D. ; Kirkland, James L. ; Yung, Raymond. / Models and Studies of Aging : Executive Summary of a Report from the U13 Conference Series. In: Journal of the American Geriatrics Society. 2019 ; Vol. 67, No. 3. pp. 428-433.

@article{09042ad1ab5e48d7af9a73324db2b11f,

title = "Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series",

abstract = "The American Geriatrics Society convened a conference in Bethesda, Maryland, to explore models and studies of aging. This was the second of three conferences, supported by a U13 grant from the National Institute on Aging, to aid recipients of Grants for Early Medical/Surgical Specialists Transition to Aging Research (GEMSSTAR) in integrating geriatrics into their specialties. Recognizing that aging is the largest risk factor for multiple chronic diseases and age-related loss of resilience, the conference organizers focused scientific sessions on how targeting age-related mechanisms can delay, prevent, or reverse geriatric syndromes, age-related chronic diseases, and loss of resilience. The rationale for studying models of aging as well as study designs, strategies, and challenges of studying human aging were reviewed. This article provides a summary of the full conference report, Models and Studies of Aging: Report from the U13 Conference Series, and summarizes key take-home messages that were designed to support GEMSSTAR awardees in developing their research careers focused on aging research (see supplementary text for the full report). J Am Geriatr Soc 67:428–433, 2019.",

keywords = "aging, biology, geriatrics, research",

author = "Arti Hurria and Carpenter, {Christopher R.} and Frances McFarland and Lundebjerg, {Nancy E.} and {de Cabo}, Rafael and Luigi Ferrucci and Studenski, {Stephanie A.} and Nir Barzilai and Briggs, {Josephine P.} and Ix, {Joachim H.} and Kitzman, {Dalane W.} and Kuchel, {George A.} and Nicolas Musi and Newman, {John C.} and Rando, {Thomas A.} and Smith, {Alexander K.} and Walston, {Jeremy D.} and Kirkland, {James L.} and Raymond Yung",

note = "Funding Information: O n September 21-23, 2016, the American Geriatrics Society convened a conference in Bethesda, Maryland, to explore models and studies of aging. This was the second of three conferences, supported by a U13 grant from the National Institute on Aging (NIA) that focuses on assisting recipients of Grants for Early Medical/Surgical Specialists Transition to Aging Research (GEMSSTAR) to integrate geriatrics into their subspecialties. The GEMSSTAR program builds on the success of two programs that were funded by the Atlantic Philanthropies and the John A. Hartford Foundation, Inc. (the T. Franklin Williams and Dennis W. Jahnigen Scholars Awards).1–3 The goals for each of the U13 conferences were twofold. The first goal was to introduce participants to key concepts and approaches that are important to understand when undertaking research on aging. The second goal was to help GEMSSTAR awardees prepare for the next stage of their research careers and to build the GEMSSTAR collaborative network. Drs. James Kirkland, of the Mayo Clinic, and Raymond Yung, of the University of Michigan, served as co-chairs for this Funding Information: Conflict of Interest: Christopher R. Carpenter was a speaker for Emergency Medical Abstracts and Best Evidence in Emergency Medicine. He also serves as a board member for Schwartz/Reisman Emergency Medicine Institute international advisory board, deputy editor-in-chief of Academic Emergency Medicine, and associate editor of the Journal of the American Geriatrics Society. George A. Kuchel receives the following grant funding from NIA: AG048023, AG021600, AG052608, and AG056925. Arti Hurria received research funding from GSK, Celgene, and Novartis. She served as a consultant for MJH Healthcare Holdings LLC, Pierian Biosciences, Boehringer Ingelheim Pharmaceuticals. and Sanofi. She served as a board member for ASCO. Luigi Ferrucci serves as an associate editor of the Journal of the American Geriatrics Society. James L. Kirkland receives NIH grant funding (R37AG 13,925, R33AG 61,456 [Translational Geroscience Network]) and support from the Connor Group, Robert J. and Theresa W. Ryan, and the Noaber, Ted Nash Long Life, and Glenn Foundations. Nicolas Musi receives the following grant funding from NIA: AG030979, AG04427, AG013319, DK80157, and DK089229. The remaining authors have declared no conflicts of interest for this article. Funding Information: Conflict of Interest: Christopher R. Carpenter was a speaker for Emergency Medical Abstracts and Best Evidence in Emergency Medicine. He also serves as a board member for Schwartz/Reisman Emergency Medicine Institute international advisory board, deputy editor-in-chief of Academic Emergency Medicine, and associate editor of the Journal of the American Geriatrics Society. George A. Kuchel receives the following grant funding from NIA: AG048023, AG021600, AG052608, and AG056925. Arti Hurria received research funding from GSK, Celgene, and Novartis. She served as a consultant for MJH Healthcare Holdings LLC, Pierian Biosciences, Boehringer Ingelheim Pharmaceuticals. and Sanofi. She served as a board member for ASCO. Luigi Ferrucci serves as an associate editor of the Journal of the American Geriatrics Society. James L. Kirkland receives NIH grant funding (R37AG 13,925, R33AG 61,456 [Translational Geroscience Network]) and support from the Connor Group, Robert J. and Theresa W. Ryan, and the Noaber, Ted Nash Long Life, and Glenn Foundations. Nicolas Musi receives the following grant funding from NIA: AG030979, AG04427, AG013319, DK80157, and DK089229. The remaining authors have declared no conflicts of interest for this article. Author Contributions: Concept and design: Briggs, Barzilai, DeCabo, Ferrucci, Hurria, Ix, Kitzman, Kirkland, Musi, Newman, Rando, Smith, Studenski, Walston, and Yung. Analysis and interpretation of data: Hurria, Ix, and Kitzman. Preparation of the manuscript: Briggs, Carpenter, DeCabo, Ferrucci, Hurria, Kitzman, Kuchel, Kirkland, McFarland, Musi, Rando, Smith, Studenski, Walston, and Yung. Sponsor's Role: Funding for this conference was made possible, in part, by 5 U13 AG 048721-04 from the National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the US government. The authors would like to thank Frances McFarland, PhD, and Rachel Morrison, PhD, for their assistance in the preparation of this manuscript. The authors would also like to thank Sue Zieman, MD, PhD, Basil Eldadah, MD, PhD, Evan Hadley, MD, Robin Barr, PhD, and Marcel Salive, MD, PhD, for their support of the conference and manuscript. This report was reviewed by all workshop speakers. We humbly dedicate this mentorship essay to our co-author, GEMSSTAR U13 principal investigator, friend, and hero Arti Hurria who lost her life on November 7, 2018. Publisher Copyright: {\textcopyright} 2019 The American Geriatrics Society",

year = "2019",

month = mar,

doi = "10.1111/jgs.15788",

language = "English",

volume = "67",

pages = "428--433",

journal = "Journal of the American Geriatrics Society",

issn = "0002-8614",

number = "3",

}

Hurria, A, Carpenter, CR, McFarland, F, Lundebjerg, NE, de Cabo, R, Ferrucci, L, Studenski, SA, Barzilai, N, Briggs, JP, Ix, JH, Kitzman, DW, Kuchel, GA, Musi, N, Newman, JC, Rando, TA, Smith, AK, Walston, JD, Kirkland, JL & Yung, R 2019, 'Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series', Journal of the American Geriatrics Society, vol. 67, no. 3, pp. 428-433. https://doi.org/10.1111/jgs.15788

Models and Studies of Aging : Executive Summary of a Report from the U13 Conference Series. / Hurria, Arti; Carpenter, Christopher R.; McFarland, Frances; Lundebjerg, Nancy E.; de Cabo, Rafael; Ferrucci, Luigi; Studenski, Stephanie A.; Barzilai, Nir; Briggs, Josephine P.; Ix, Joachim H.; Kitzman, Dalane W.; Kuchel, George A.; Musi, Nicolas; Newman, John C.; Rando, Thomas A.; Smith, Alexander K.; Walston, Jeremy D.; Kirkland, James L.; Yung, Raymond.

In: Journal of the American Geriatrics Society, Vol. 67, No. 3, 03.2019, p. 428-433.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Models and Studies of Aging

T2 - Executive Summary of a Report from the U13 Conference Series

AU - Hurria, Arti

AU - Carpenter, Christopher R.

AU - McFarland, Frances

AU - Lundebjerg, Nancy E.

AU - de Cabo, Rafael

AU - Ferrucci, Luigi

AU - Studenski, Stephanie A.

AU - Barzilai, Nir

AU - Briggs, Josephine P.

AU - Ix, Joachim H.

AU - Kitzman, Dalane W.

AU - Kuchel, George A.

AU - Musi, Nicolas

AU - Newman, John C.

AU - Rando, Thomas A.

AU - Smith, Alexander K.

AU - Walston, Jeremy D.

AU - Kirkland, James L.

AU - Yung, Raymond

N1 - Funding Information: O n September 21-23, 2016, the American Geriatrics Society convened a conference in Bethesda, Maryland, to explore models and studies of aging. This was the second of three conferences, supported by a U13 grant from the National Institute on Aging (NIA) that focuses on assisting recipients of Grants for Early Medical/Surgical Specialists Transition to Aging Research (GEMSSTAR) to integrate geriatrics into their subspecialties. The GEMSSTAR program builds on the success of two programs that were funded by the Atlantic Philanthropies and the John A. Hartford Foundation, Inc. (the T. Franklin Williams and Dennis W. Jahnigen Scholars Awards).1–3 The goals for each of the U13 conferences were twofold. The first goal was to introduce participants to key concepts and approaches that are important to understand when undertaking research on aging. The second goal was to help GEMSSTAR awardees prepare for the next stage of their research careers and to build the GEMSSTAR collaborative network. Drs. James Kirkland, of the Mayo Clinic, and Raymond Yung, of the University of Michigan, served as co-chairs for this Funding Information: Conflict of Interest: Christopher R. Carpenter was a speaker for Emergency Medical Abstracts and Best Evidence in Emergency Medicine. He also serves as a board member for Schwartz/Reisman Emergency Medicine Institute international advisory board, deputy editor-in-chief of Academic Emergency Medicine, and associate editor of the Journal of the American Geriatrics Society. George A. Kuchel receives the following grant funding from NIA: AG048023, AG021600, AG052608, and AG056925. Arti Hurria received research funding from GSK, Celgene, and Novartis. She served as a consultant for MJH Healthcare Holdings LLC, Pierian Biosciences, Boehringer Ingelheim Pharmaceuticals. and Sanofi. She served as a board member for ASCO. Luigi Ferrucci serves as an associate editor of the Journal of the American Geriatrics Society. James L. Kirkland receives NIH grant funding (R37AG 13,925, R33AG 61,456 [Translational Geroscience Network]) and support from the Connor Group, Robert J. and Theresa W. Ryan, and the Noaber, Ted Nash Long Life, and Glenn Foundations. Nicolas Musi receives the following grant funding from NIA: AG030979, AG04427, AG013319, DK80157, and DK089229. The remaining authors have declared no conflicts of interest for this article. Funding Information: Conflict of Interest: Christopher R. Carpenter was a speaker for Emergency Medical Abstracts and Best Evidence in Emergency Medicine. He also serves as a board member for Schwartz/Reisman Emergency Medicine Institute international advisory board, deputy editor-in-chief of Academic Emergency Medicine, and associate editor of the Journal of the American Geriatrics Society. George A. Kuchel receives the following grant funding from NIA: AG048023, AG021600, AG052608, and AG056925. Arti Hurria received research funding from GSK, Celgene, and Novartis. She served as a consultant for MJH Healthcare Holdings LLC, Pierian Biosciences, Boehringer Ingelheim Pharmaceuticals. and Sanofi. She served as a board member for ASCO. Luigi Ferrucci serves as an associate editor of the Journal of the American Geriatrics Society. James L. Kirkland receives NIH grant funding (R37AG 13,925, R33AG 61,456 [Translational Geroscience Network]) and support from the Connor Group, Robert J. and Theresa W. Ryan, and the Noaber, Ted Nash Long Life, and Glenn Foundations. Nicolas Musi receives the following grant funding from NIA: AG030979, AG04427, AG013319, DK80157, and DK089229. The remaining authors have declared no conflicts of interest for this article. Author Contributions: Concept and design: Briggs, Barzilai, DeCabo, Ferrucci, Hurria, Ix, Kitzman, Kirkland, Musi, Newman, Rando, Smith, Studenski, Walston, and Yung. Analysis and interpretation of data: Hurria, Ix, and Kitzman. Preparation of the manuscript: Briggs, Carpenter, DeCabo, Ferrucci, Hurria, Kitzman, Kuchel, Kirkland, McFarland, Musi, Rando, Smith, Studenski, Walston, and Yung. Sponsor's Role: Funding for this conference was made possible, in part, by 5 U13 AG 048721-04 from the National Institute on Aging. The views expressed in written conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply endorsement by the US government. The authors would like to thank Frances McFarland, PhD, and Rachel Morrison, PhD, for their assistance in the preparation of this manuscript. The authors would also like to thank Sue Zieman, MD, PhD, Basil Eldadah, MD, PhD, Evan Hadley, MD, Robin Barr, PhD, and Marcel Salive, MD, PhD, for their support of the conference and manuscript. This report was reviewed by all workshop speakers. We humbly dedicate this mentorship essay to our co-author, GEMSSTAR U13 principal investigator, friend, and hero Arti Hurria who lost her life on November 7, 2018. Publisher Copyright: © 2019 The American Geriatrics Society

PY - 2019/3

Y1 - 2019/3

N2 - The American Geriatrics Society convened a conference in Bethesda, Maryland, to explore models and studies of aging. This was the second of three conferences, supported by a U13 grant from the National Institute on Aging, to aid recipients of Grants for Early Medical/Surgical Specialists Transition to Aging Research (GEMSSTAR) in integrating geriatrics into their specialties. Recognizing that aging is the largest risk factor for multiple chronic diseases and age-related loss of resilience, the conference organizers focused scientific sessions on how targeting age-related mechanisms can delay, prevent, or reverse geriatric syndromes, age-related chronic diseases, and loss of resilience. The rationale for studying models of aging as well as study designs, strategies, and challenges of studying human aging were reviewed. This article provides a summary of the full conference report, Models and Studies of Aging: Report from the U13 Conference Series, and summarizes key take-home messages that were designed to support GEMSSTAR awardees in developing their research careers focused on aging research (see supplementary text for the full report). J Am Geriatr Soc 67:428–433, 2019.

AB - The American Geriatrics Society convened a conference in Bethesda, Maryland, to explore models and studies of aging. This was the second of three conferences, supported by a U13 grant from the National Institute on Aging, to aid recipients of Grants for Early Medical/Surgical Specialists Transition to Aging Research (GEMSSTAR) in integrating geriatrics into their specialties. Recognizing that aging is the largest risk factor for multiple chronic diseases and age-related loss of resilience, the conference organizers focused scientific sessions on how targeting age-related mechanisms can delay, prevent, or reverse geriatric syndromes, age-related chronic diseases, and loss of resilience. The rationale for studying models of aging as well as study designs, strategies, and challenges of studying human aging were reviewed. This article provides a summary of the full conference report, Models and Studies of Aging: Report from the U13 Conference Series, and summarizes key take-home messages that were designed to support GEMSSTAR awardees in developing their research careers focused on aging research (see supplementary text for the full report). J Am Geriatr Soc 67:428–433, 2019.

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KW - biology

KW - geriatrics

KW - research

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U2 - 10.1111/jgs.15788

DO - 10.1111/jgs.15788

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VL - 67

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EP - 433

JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

IS - 3

ER -

Models and Studies of Aging: Executive Summary of a Report from the U13 Conference Series

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