Models and applications of in vivo lung morphometry with hyperpolarized 3He MRI in a mild COPD population

Research output: Contribution to journalConference articlepeer-review

1 Scopus citations

Abstract

Hyperpolarized 3He diffusion MRI is increasingly used to non-invasively quantify local alveolar structure changes, such as those from Chronic Obstructive Pulmonary Disease (COPD). Previously, we described an in vivo lung morphometry technique that decouples the helium apparent diffusion coefficient (ADC) into components oriented along the longitudinal (DL) and transverse (DT) axes of the acinar airways. Herein, we discuss our recent expansion of this theory, which relates the anisotropy of the MRI diffusion signal to the geometrical parameters of the acinar airways. We demonstrate the utility of this model in human studies and compare the measured airway radii with prior ex vivo experiments.

Original languageEnglish
Pages (from-to)29-31
Number of pages3
JournalAIP Conference Proceedings
Volume1081
DOIs
StatePublished - Dec 1 2008
Event9th International Bologna Conference on Magnetic Resonance in Porous Media, MRPM9 - Cambridge, MA, United States
Duration: Jul 13 2008Jul 17 2008

Keywords

  • COPD
  • Diffusion
  • MRI

Fingerprint Dive into the research topics of 'Models and applications of in vivo lung morphometry with hyperpolarized 3He MRI in a mild COPD population'. Together they form a unique fingerprint.

Cite this