Models and applications of in vivo lung morphometry with hyperpolarized 3He MRI in a mild COPD population

James D. Quirk; Alexander L. Sukstanskii; David S. Gierada; Jason C. Woods; Mark S. Conradi; Dmitriy A. Yablonskiy

doi:10.1063/1.3058539

Models and applications of in vivo lung morphometry with hyperpolarized 3He MRI in a mild COPD population

James D. Quirk, Alexander L. Sukstanskii, David S. Gierada, Jason C. Woods, Mark S. Conradi, Dmitriy A. Yablonskiy

Research output: Contribution to journal › Conference article › peer-review

1 Scopus citations

Abstract

Hyperpolarized 3He diffusion MRI is increasingly used to non-invasively quantify local alveolar structure changes, such as those from Chronic Obstructive Pulmonary Disease (COPD). Previously, we described an in vivo lung morphometry technique that decouples the helium apparent diffusion coefficient (ADC) into components oriented along the longitudinal (D_L) and transverse (D_T) axes of the acinar airways. Herein, we discuss our recent expansion of this theory, which relates the anisotropy of the MRI diffusion signal to the geometrical parameters of the acinar airways. We demonstrate the utility of this model in human studies and compare the measured airway radii with prior ex vivo experiments.

Original language	English
Pages (from-to)	29-31
Number of pages	3
Journal	AIP Conference Proceedings
Volume	1081
DOIs	https://doi.org/10.1063/1.3058539
State	Published - 2008
Event	9th International Bologna Conference on Magnetic Resonance in Porous Media, MRPM9 - Cambridge, MA, United States Duration: Jul 13 2008 → Jul 17 2008

Keywords

COPD
Diffusion
MRI

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title = "Models and applications of in vivo lung morphometry with hyperpolarized 3He MRI in a mild COPD population",

abstract = "Hyperpolarized 3He diffusion MRI is increasingly used to non-invasively quantify local alveolar structure changes, such as those from Chronic Obstructive Pulmonary Disease (COPD). Previously, we described an in vivo lung morphometry technique that decouples the helium apparent diffusion coefficient (ADC) into components oriented along the longitudinal (DL) and transverse (DT) axes of the acinar airways. Herein, we discuss our recent expansion of this theory, which relates the anisotropy of the MRI diffusion signal to the geometrical parameters of the acinar airways. We demonstrate the utility of this model in human studies and compare the measured airway radii with prior ex vivo experiments.",

keywords = "COPD, Diffusion, MRI",

author = "Quirk, {James D.} and Sukstanskii, {Alexander L.} and Gierada, {David S.} and Woods, {Jason C.} and Conradi, {Mark S.} and Yablonskiy, {Dmitriy A.}",

year = "2008",

doi = "10.1063/1.3058539",

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volume = "1081",

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T1 - Models and applications of in vivo lung morphometry with hyperpolarized 3He MRI in a mild COPD population

AU - Quirk, James D.

AU - Sukstanskii, Alexander L.

AU - Gierada, David S.

AU - Woods, Jason C.

AU - Conradi, Mark S.

AU - Yablonskiy, Dmitriy A.

PY - 2008

Y1 - 2008

N2 - Hyperpolarized 3He diffusion MRI is increasingly used to non-invasively quantify local alveolar structure changes, such as those from Chronic Obstructive Pulmonary Disease (COPD). Previously, we described an in vivo lung morphometry technique that decouples the helium apparent diffusion coefficient (ADC) into components oriented along the longitudinal (DL) and transverse (DT) axes of the acinar airways. Herein, we discuss our recent expansion of this theory, which relates the anisotropy of the MRI diffusion signal to the geometrical parameters of the acinar airways. We demonstrate the utility of this model in human studies and compare the measured airway radii with prior ex vivo experiments.

AB - Hyperpolarized 3He diffusion MRI is increasingly used to non-invasively quantify local alveolar structure changes, such as those from Chronic Obstructive Pulmonary Disease (COPD). Previously, we described an in vivo lung morphometry technique that decouples the helium apparent diffusion coefficient (ADC) into components oriented along the longitudinal (DL) and transverse (DT) axes of the acinar airways. Herein, we discuss our recent expansion of this theory, which relates the anisotropy of the MRI diffusion signal to the geometrical parameters of the acinar airways. We demonstrate the utility of this model in human studies and compare the measured airway radii with prior ex vivo experiments.

KW - COPD

KW - Diffusion

KW - MRI

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DO - 10.1063/1.3058539

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VL - 1081

SP - 29

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JF - AIP Conference Proceedings

T2 - 9th International Bologna Conference on Magnetic Resonance in Porous Media, MRPM9

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ER -

Models and applications of in vivo lung morphometry with hyperpolarized 3He MRI in a mild COPD population

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