Hyperpolarized 3He diffusion MRI is increasingly used to non-invasively quantify local alveolar structure changes, such as those from Chronic Obstructive Pulmonary Disease (COPD). Previously, we described an in vivo lung morphometry technique that decouples the helium apparent diffusion coefficient (ADC) into components oriented along the longitudinal (DL) and transverse (DT) axes of the acinar airways. Herein, we discuss our recent expansion of this theory, which relates the anisotropy of the MRI diffusion signal to the geometrical parameters of the acinar airways. We demonstrate the utility of this model in human studies and compare the measured airway radii with prior ex vivo experiments.
|Number of pages||3|
|Journal||AIP Conference Proceedings|
|State||Published - Dec 1 2008|
|Event||9th International Bologna Conference on Magnetic Resonance in Porous Media, MRPM9 - Cambridge, MA, United States|
Duration: Jul 13 2008 → Jul 17 2008