TY - JOUR
T1 - Modeling the behavior of coupled cellular circadian oscillators in the suprachiasmatic nucleus
AU - Indic, Premananda
AU - Schwartz, William J.
AU - Herzog, Erik D.
AU - Foley, Nicholas C.
AU - Antle, Michael C.
PY - 2007/6
Y1 - 2007/6
N2 - The suprachiasmatic nucleus (SCN) in the hypothalamus is the site of the master circadian clock in mammals, a complex tissue composed of multiple, coupled, single-cell circadian oscillators. Mathematical modeling is now providing insights on how individual SCN cells might interact and assemble to create an integrated pacemaker that governs the circadian behavior of whole animals. In this article, we will discuss the neurobiological constraints for modeling SCN behavior, system precision, implications of cellular heterogeneity, and analysis of heterogeneously coupled oscillator networks. Mathematical approaches will be critical for better understanding intercellular interactions within the SCN.
AB - The suprachiasmatic nucleus (SCN) in the hypothalamus is the site of the master circadian clock in mammals, a complex tissue composed of multiple, coupled, single-cell circadian oscillators. Mathematical modeling is now providing insights on how individual SCN cells might interact and assemble to create an integrated pacemaker that governs the circadian behavior of whole animals. In this article, we will discuss the neurobiological constraints for modeling SCN behavior, system precision, implications of cellular heterogeneity, and analysis of heterogeneously coupled oscillator networks. Mathematical approaches will be critical for better understanding intercellular interactions within the SCN.
KW - Coupled oscillators
KW - Kuramoto model
KW - Suprachiasmatic nucleus
UR - https://www.scopus.com/pages/publications/34249101240
U2 - 10.1177/0748730407301238
DO - 10.1177/0748730407301238
M3 - Article
C2 - 17517911
AN - SCOPUS:34249101240
SN - 0748-7304
VL - 22
SP - 211
EP - 219
JO - Journal of Biological Rhythms
JF - Journal of Biological Rhythms
IS - 3
ER -