Modeling participant-related clinical research events using conceptual knowledge acquisition techniques.

Philip R.O. Payne, Eneida A. Mendonca, Justin B. Starren

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The active phase of a clinical trial is defined by a protocol schema consisting of participant-related events organized into multiple visits. Current efforts to model protocol schemas in a computable format have focused on high-level abstractions, such as the temporal relationships between visits. However, such approaches do not address the need for a more granular computational model of the individual events that comprise each visit. To address the preceding gap in knowledge, this paper will describe a study in which conceptual knowledge acquisition (CKA) techniques were applied to a corpus of 32 clinical trials protocol documents in order to develop a knowledge collection of common participant-related clinical research events. These techniques identified 7 high-level concepts that could be used as organizing principles in the resulting knowledge collection. Such results confirm the utility of CKA methods in the clinical research domain.

Original languageEnglish
Pages (from-to)593-597
Number of pages5
JournalAMIA ... Annual Symposium proceedings / AMIA Symposium. AMIA Symposium
StatePublished - 2007

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