Modeling murine gastric metaplasia through tamoxifen-induced acute parietal cell loss

Jose B. Saenz, Joseph Burclaff, Jason C. Mills

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Parietal cell loss represents the initial step in the sequential progression toward gastric adenocarcinoma. In the setting of chronic inflammation, the expansion of the mucosal response to parietal cell loss characterizes a crucial transition en route to gastric dysplasia. Here, we detail methods for using the selective estrogen receptor modulator tamoxifen as a novel tool to rapidly and reversibly induce parietal cell loss in mice in order to study the mechanisms that underlie these pre-neoplastic events.

Original languageEnglish
Pages (from-to)329-339
Number of pages11
JournalMethods in Molecular Biology
Volume1422
DOIs
StatePublished - Jan 1 2016
Externally publishedYes

Keywords

  • Metaplasia
  • Oxyntic atrophy
  • Parietal cell loss
  • Spasmolytic polypeptideexpressing metaplasia (SPEM)
  • Tamoxifen

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