TY - JOUR
T1 - Modeling large-scale dynamic processes in the cell
T2 - Polarization, waves, and division
AU - Sept, David
AU - Carlsson, Anders E.
PY - 2014/8
Y1 - 2014/8
N2 - The past decade has witnessed significant developments in molecular biology techniques, fluorescent labeling, and super-resolution microscopy, and together these advances have vastly increased our quantitative understanding of the cell. This detailed knowledge has concomitantly opened the door for biophysical modeling on a cellular scale. There have been comprehensive models produced describing many processes such as motility, transport, gene regulation, and chemotaxis. However, in this review we focus on a specific set of phenomena, namely cell polarization, F-actin waves, and cytokinesis. In each case, we compare and contrast various published models, highlight the relevant aspects of the biology, and provide a sense of the direction in which the field is moving.
AB - The past decade has witnessed significant developments in molecular biology techniques, fluorescent labeling, and super-resolution microscopy, and together these advances have vastly increased our quantitative understanding of the cell. This detailed knowledge has concomitantly opened the door for biophysical modeling on a cellular scale. There have been comprehensive models produced describing many processes such as motility, transport, gene regulation, and chemotaxis. However, in this review we focus on a specific set of phenomena, namely cell polarization, F-actin waves, and cytokinesis. In each case, we compare and contrast various published models, highlight the relevant aspects of the biology, and provide a sense of the direction in which the field is moving.
UR - http://www.scopus.com/inward/record.url?scp=84915784951&partnerID=8YFLogxK
U2 - 10.1017/S0033583514000079
DO - 10.1017/S0033583514000079
M3 - Article
C2 - 25124728
AN - SCOPUS:84915784951
SN - 0033-5835
VL - 47
SP - 221
EP - 248
JO - Quarterly Reviews of Biophysics
JF - Quarterly Reviews of Biophysics
IS - 3
ER -