Modeling large-scale dynamic processes in the cell: Polarization, waves, and division

David Sept, Anders E. Carlsson

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

The past decade has witnessed significant developments in molecular biology techniques, fluorescent labeling, and super-resolution microscopy, and together these advances have vastly increased our quantitative understanding of the cell. This detailed knowledge has concomitantly opened the door for biophysical modeling on a cellular scale. There have been comprehensive models produced describing many processes such as motility, transport, gene regulation, and chemotaxis. However, in this review we focus on a specific set of phenomena, namely cell polarization, F-actin waves, and cytokinesis. In each case, we compare and contrast various published models, highlight the relevant aspects of the biology, and provide a sense of the direction in which the field is moving.

Original languageEnglish
Pages (from-to)221-248
Number of pages28
JournalQuarterly Reviews of Biophysics
Volume47
Issue number3
DOIs
StatePublished - Aug 2014

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