Abstract
A mathematical model of the cardiac ventricular cell (the L-R model) is used to describe ionic currents and dynamic concentration changes during the action potential. The role of the fast and slow components of the delayed rectifier potassium current in repolarization is investigated. The model is also used to study arrhythmogenic activity of the single cell including early afterdepolarizations (EADs), delayed afterdepolarizations (DADs), and rhythmic (spontaneous and triggered activity during calcium overload. In addition, effects of various pharmacological agents on cellular behavior are simulated.
| Original language | English |
|---|---|
| Pages (from-to) | 9-10 |
| Number of pages | 2 |
| Journal | Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings |
| Volume | 17 |
| Issue number | 1 |
| State | Published - 1995 |
| Event | Proceedings of the 1995 IEEE Engineering in Medicine and Biology 17th Annual Conference and 21st Canadian Medical and Biological Engineering Conference. Part 2 (of 2) - Montreal, Can Duration: Sep 20 1995 → Sep 23 1995 |