Modeling axonal degeneration within the anterior visual system: Implications for demonstrating neuroprotection in multiple sclerosis

Elliot M. Frohman; Fiona Costello; Olaf Stüve; Peter Calabresi; David H. Miller; Simon J. Hickman; Robert Sergott; Amy Conger; Amber Salter; Kimberly H. Krumwiede; Teresa C. Frohman; Laura Balcer; Robert Zivadinov

doi:10.1001/archneurol.2007.10

Modeling axonal degeneration within the anterior visual system: Implications for demonstrating neuroprotection in multiple sclerosis

Elliot M. Frohman, Fiona Costello, Olaf Stüve, Peter Calabresi, David H. Miller, Simon J. Hickman, Robert Sergott, Amy Conger, Amber Salter, Kimberly H. Krumwiede, Teresa C. Frohman, Laura Balcer, Robert Zivadinov

Institute for Informatics, Data Science and Biostatistics (I2DB)

Research output: Contribution to journal › Review article › peer-review

62 Scopus citations

Abstract

A major objective in multiple sclerosis therapeutics is to develop strategic targeting of specific injury pathways to provide neuroprotection and potentially even restoration. Here we underscore the potential utility of the anterior visual system for the purpose of modeling neuroprotection in response to novel therapies.

Original language	English
Pages (from-to)	26-35
Number of pages	10
Journal	Archives of neurology
Volume	65
Issue number	1
DOIs	https://doi.org/10.1001/archneurol.2007.10
State	Published - Jan 2008

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Frohman, E. M., Costello, F., Stüve, O., Calabresi, P., Miller, D. H., Hickman, S. J., Sergott, R., Conger, A., Salter, A., Krumwiede, K. H., Frohman, T. C., Balcer, L., & Zivadinov, R. (2008). Modeling axonal degeneration within the anterior visual system: Implications for demonstrating neuroprotection in multiple sclerosis. Archives of neurology, 65(1), 26-35. https://doi.org/10.1001/archneurol.2007.10

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title = "Modeling axonal degeneration within the anterior visual system: Implications for demonstrating neuroprotection in multiple sclerosis",

abstract = "A major objective in multiple sclerosis therapeutics is to develop strategic targeting of specific injury pathways to provide neuroprotection and potentially even restoration. Here we underscore the potential utility of the anterior visual system for the purpose of modeling neuroprotection in response to novel therapies.",

author = "Frohman, {Elliot M.} and Fiona Costello and Olaf St{\"u}ve and Peter Calabresi and Miller, {David H.} and Hickman, {Simon J.} and Robert Sergott and Amy Conger and Amber Salter and Krumwiede, {Kimberly H.} and Frohman, {Teresa C.} and Laura Balcer and Robert Zivadinov",

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Frohman, EM, Costello, F, Stüve, O, Calabresi, P, Miller, DH, Hickman, SJ, Sergott, R, Conger, A, Salter, A, Krumwiede, KH, Frohman, TC, Balcer, L & Zivadinov, R 2008, 'Modeling axonal degeneration within the anterior visual system: Implications for demonstrating neuroprotection in multiple sclerosis', Archives of neurology, vol. 65, no. 1, pp. 26-35. https://doi.org/10.1001/archneurol.2007.10

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T1 - Modeling axonal degeneration within the anterior visual system

T2 - Implications for demonstrating neuroprotection in multiple sclerosis

AU - Frohman, Elliot M.

AU - Costello, Fiona

AU - Stüve, Olaf

AU - Calabresi, Peter

AU - Miller, David H.

AU - Hickman, Simon J.

AU - Sergott, Robert

AU - Conger, Amy

AU - Salter, Amber

AU - Krumwiede, Kimberly H.

AU - Frohman, Teresa C.

AU - Balcer, Laura

AU - Zivadinov, Robert

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N2 - A major objective in multiple sclerosis therapeutics is to develop strategic targeting of specific injury pathways to provide neuroprotection and potentially even restoration. Here we underscore the potential utility of the anterior visual system for the purpose of modeling neuroprotection in response to novel therapies.

AB - A major objective in multiple sclerosis therapeutics is to develop strategic targeting of specific injury pathways to provide neuroprotection and potentially even restoration. Here we underscore the potential utility of the anterior visual system for the purpose of modeling neuroprotection in response to novel therapies.

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U2 - 10.1001/archneurol.2007.10

DO - 10.1001/archneurol.2007.10

M3 - Review article

C2 - 18195137

AN - SCOPUS:38349038413

SN - 0003-9942

VL - 65

SP - 26

EP - 35

JO - Archives of neurology

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Modeling axonal degeneration within the anterior visual system: Implications for demonstrating neuroprotection in multiple sclerosis

Abstract

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