TY - JOUR
T1 - Model study of protein unfolding by interfaces
AU - Chakarova, S. D.
AU - Carlsson, A. E.
PY - 2004/2
Y1 - 2004/2
N2 - Interface-induced protein unfolding on hydrophobic and polar interfaces was studed using a two-dimensional lattice model. It was suggested that the unfolding proceeds by a large, sudden loss of native contacts. The results show that the unfolding at polar interfaces exhibits similar behavior to that at hydrophobic interfaces but with a much weaker interface coupling strength. It was also found that the resistance of proteins to unfolding in the model is positively correlated with the magnitude of the folding energy in the native-state structure, energy gap for that structure and the interface energy for native-state adsorption.
AB - Interface-induced protein unfolding on hydrophobic and polar interfaces was studed using a two-dimensional lattice model. It was suggested that the unfolding proceeds by a large, sudden loss of native contacts. The results show that the unfolding at polar interfaces exhibits similar behavior to that at hydrophobic interfaces but with a much weaker interface coupling strength. It was also found that the resistance of proteins to unfolding in the model is positively correlated with the magnitude of the folding energy in the native-state structure, energy gap for that structure and the interface energy for native-state adsorption.
UR - http://www.scopus.com/inward/record.url?scp=37649026588&partnerID=8YFLogxK
U2 - 10.1103/PhysRevE.69.021907
DO - 10.1103/PhysRevE.69.021907
M3 - Article
C2 - 14995491
AN - SCOPUS:37649026588
SN - 1063-651X
VL - 69
SP - 021907-1-021907-9
JO - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
JF - Physical Review E - Statistical, Nonlinear, and Soft Matter Physics
IS - 2 1
M1 - 021907
ER -