Model studies with enzyme inhibitors. Addition of nucleophiles to conjugated allenic 3-oxo-5,10-secosteroids

Douglas F. Covey, Katherine A. Albert, Cecil H. Robinson

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

The Michael addition of nucleophiles to the enzyme inhibitor 5,10-seco-oestra-4,5-diene-3,10,17-trione (2) gives 5,10-seco-oestr-5-ene derivatives (3) or A-homo-B-noroestr-4-ene derivatives (4) depending on the nucleophile.

Original languageEnglish
Pages (from-to)795-796
Number of pages2
JournalJournal of the Chemical Society, Chemical Communications
Issue number18
DOIs
StatePublished - Dec 1 1979
Externally publishedYes

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