Model-Based Methods for Linkage Analysis

John P. Rice, Nancy L. Saccone, Jonathan Corbett

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Scopus citations

Abstract

The logarithm of an odds ratio (LOD) score method originated in a seminal article by Newton Morton in 1955. The method is broadly concerned with issues of power and the posterior probability of linkage, ensuring that a reported linkage has a high probability of being a true linkage. In addition, the method is sequential so that pedigrees or LOD curves may be combined from published reports to pool data for analysis. This approach has been remarkably successful for 50 years in identifying disease genes for Mendelian disorders. After discussing these issues, we consider the situation for complex disorders where the maximum LOD score statistic shares some of the advantages of the traditional LOD score approach, but is limited by unknown power and the lack of sharing of the primary data needed to optimally combine analytic results. We may still learn from the LOD score method as we explore new methods in molecular biology and genetic analysis to utilize the complete human DNA sequence and the cataloging of all human genes.

Original languageEnglish
Title of host publicationGenetic Dissection of Complex Traits
EditorsD.C. Rao, Charles Gu
Pages155-173
Number of pages19
DOIs
StatePublished - Mar 20 2008

Publication series

NameAdvances in Genetics
Volume60
ISSN (Print)0065-2660

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    Rice, J. P., Saccone, N. L., & Corbett, J. (2008). Model-Based Methods for Linkage Analysis. In D. C. Rao, & C. Gu (Eds.), Genetic Dissection of Complex Traits (pp. 155-173). (Advances in Genetics; Vol. 60). https://doi.org/10.1016/S0065-2660(07)00407-5