Mobilization of Peripheral Blood Hematopoietic Cells for Autologous HCT

Thomas C. Shea, John F. DiPersio

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

4 Scopus citations

Abstract

The following chapter describes the underlying biology and clinical techniques involved in the process of stem and progenitor cell identification, enumeration, mobilization, and collection prior to autologous stem cell transplantation (ASCT). A description of established as well as novel and potential future methods for augmenting the yields of these cells in normal and hard-to-mobilize situations will be provided. A significant component of this chapter will be devoted to a description of the recent advances in this field, especially in regards to the use of chemokine antagonists such as plerixafor to optimize the efficient and cost-effective collection of these cells.

Original languageEnglish
Title of host publicationThomas' Hematopoietic Cell Transplantation
Subtitle of host publicationFifth Edition
PublisherWiley Blackwell
Pages452-462
Number of pages11
Volume1-2
ISBN (Electronic)9781118416426
ISBN (Print)9781118416006
DOIs
StatePublished - Jan 1 2016

Keywords

  • Apheresis
  • Autologous stem cell transplantation
  • Chemokines
  • Cytokines
  • Progenitor cell collection
  • Stem cell mobilization

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