Mobilization of Peripheral Blood Hematopoietic Cells for Autologous HCT

The following chapter describes the underlying biology and clinical techniques involved in the process of stem and progenitor cell identification, enumeration, mobilization, and collection prior to autologous stem cell transplantation (ASCT). A description of established as well as novel and potential future methods for augmenting the yields of these cells in normal and hard-to-mobilize situations will be provided. A significant component of this chapter will be devoted to a description of the recent advances in this field, especially in regards to the use of chemokine antagonists such as plerixafor to optimize the efficient and cost-effective collection of these cells.