23 Scopus citations

Abstract

HSC mobilization is an essential homeostatic process during inflammation and for the maintenance of hematopoietic progenitors. It has been exploited for the therapeutic application of HSC transplantation. Recent evidence suggests that leukemic cells share surface molecules in common with stem cells and may be mobilized under similar conditions. This effect could be used for therapeutic interventions. In this review, we will provide evidence showing that leukemia cells and stem cells traffic similarly and may share a common niche. Studies are discussed comparing and contrasting the mechanism of normal stem cells and leukemic cell mobilization through the CXCR4/CXCL12 axis and other key intermediaries.

Original languageEnglish
Pages (from-to)47-57
Number of pages11
JournalJournal of Leukocyte Biology
Volume91
Issue number1
DOIs
StatePublished - Jan 1 2012

Keywords

  • CXCR4
  • Integrins
  • Niche
  • Plerixafor/AMD3100
  • Stromal-derived factor-1/CXCL12

Fingerprint Dive into the research topics of 'Mobilization of hematopoietic stem and leukemia cells'. Together they form a unique fingerprint.

  • Cite this