Background: The role of the MmpL11 transporter in mycobacteria is not understood. Results: Mycobacterium smegmatis mmpL11 mutants accumulate mycolic acid precursors and fail to transport monomeromycolyl diacylglycerol and mycolate ester wax to the bacterial surface. Conclusion: MmpL11 contributes to mycobacterial cell wall biosynthesis. Significance: MmpL11 plays a conserved role in mycobacterial cell wall biogenesis that is important for M. tuberculosis virulence.
|Number of pages||10|
|Journal||Journal of Biological Chemistry|
|State||Published - Aug 16 2013|