Mixed-model segregation analysis of schizophrenia in the lindelius Swedish pedigrees

George P. Vogler, Irving I. Gottesman, Matthew K. McGue, D. C. Rao

Research output: Contribution to journalArticlepeer-review

33 Scopus citations


To test if familial transmission of schizophrenia is consistent with a model of monogenic inheritance with a multifactorial background, a mixed-model segregation analysis was applied to Swedish pedigrees consisting of 270 probands in 263 nuclear families. Results of the best-fitting mixed-model solutions are consistent with multifactorial transmission and no major gene. However, numerical instabilities prevented formal hypothesis testing, so an irrefutable genetic mechanism remains unidentified. Alternative research strategies that exploit recent advances in molecular genetics are discussed.

Original languageEnglish
Pages (from-to)461-472
Number of pages12
JournalBehavior genetics
Issue number4
StatePublished - Jul 1990


  • mixed model
  • pedigrees
  • schizophrenia
  • segregation analysis


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