Mitophagy: Therapeutic potentials for liver disease and beyond

Sooyeon Lee, Jae Sung Kim

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Mitochondrial integrity is critical for maintaining proper cellular functions. A key aspect of regulating mitochondrial homeostasis is removing damaged mitochondria through autophagy, a process called mitophagy. Autophagy dysfunction in various disease states can inactivate mitophagy and cause cell death, and defects in mitophagy are becoming increasingly recognized in a wide range of diseases from liver injuries to neurodegenerative diseases. Here we highlight our current knowledge on the mechanisms of mitophagy, and discuss how alterations in mitophagy contribute to disease pathogenesis. We also discuss mitochondrial dynamics and potential interactions between mitochondrial fusion, fission and mitophagy.

Original languageEnglish
Pages (from-to)243-250
Number of pages8
JournalToxicological Research
Volume30
Issue number4
DOIs
StatePublished - 2014

Keywords

  • Autophagy
  • Brain
  • Liver
  • Mitochondria
  • Mitophagy

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