| Original language | English |
|---|---|
| Pages (from-to) | 2201-2203 |
| Number of pages | 3 |
| Journal | Neural Regeneration Research |
| Volume | 16 |
| Issue number | 11 |
| DOIs | |
| State | Published - Nov 2021 |
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In: Neural Regeneration Research, Vol. 16, No. 11, 11.2021, p. 2201-2203.
Research output: Contribution to journal › Review article › peer-review
TY - JOUR
T1 - Mitofusin activation enhances mitochondrial motility and promotes neuroregeneration in CMT2A
AU - Dorn, Gerald
N1 - Funding Information: architecture ofsoma,linearaxonbody frommitochondrialdrop-outandneuronalin vitroarrangementmimicsin vivoneuronthatculminatesinmetabolic insufficiency References and distal branched axon. Because mouse death from mitochondrial pathway apoptosis. Baloh RH, Schmidt RE, Pestronk A, Milbrandt J CMT2A neurons grow very poorly (as in the According to this scenario, interrupting the (2007) Altered axonal mitochondrial transport above DRG studies), adeno-Cre was used cycle at any point could prove therapeutic. in the pathogenesis of Charcot-Marie-Tooth to induce hMFN2 T105M expression after Thus ? interventions like mitofusin activation 27:422-430.disease from mitofusin mutations 堀 J ?eurosci the cultured cortical neurons had grown that promote general mitochondrial Chen Y, Dorn GW 2nd (2013) PINK1- through the microchannels and developed resistance to an array of noxious insults may phosphorylated mitofusin 2 is a Parkin receptor complex arborizations 縁崃堁? 堃唀in vitro). dahyas ve broad therapeutic utility 堀 for culling damaged mitochondria. Science In this way, mature CMT2A neurons were 340:471-475. created that subsequently underwent distal The present work was supported by NIH Dang X, Zhang L, Franco A, Li J, Rocha AG, aspiration axotomy, amputating the distal R HL 唀 R NS 唀 DevanaRthan S, Dolle RE, BernsNS ?tein PR, Dorn GW branched axons while leaving the proximal and Research Grant from the 2nd (2020) Discovery of 6-phenylhexanamide linear axons intact. Amputated neurons Muscular Dystrophy Association 縁?o GWD 缃堀 derivatives as potent stereoselective mitofusin
PY - 2021/11
Y1 - 2021/11
UR - http://www.scopus.com/inward/record.url?scp=85103464737&partnerID=8YFLogxK
U2 - 10.4103/1673-5374.310684
DO - 10.4103/1673-5374.310684
M3 - Review article
C2 - 33818493
AN - SCOPUS:85103464737
SN - 1673-5374
VL - 16
SP - 2201
EP - 2203
JO - Neural Regeneration Research
JF - Neural Regeneration Research
IS - 11
ER -