Mitofusin activation enhances mitochondrial motility and promotes neuroregeneration in CMT2A

Gerald Dorn

doi:10.4103/1673-5374.310684

Mitofusin activation enhances mitochondrial motility and promotes neuroregeneration in CMT2A

Research output: Contribution to journal › Review article › peer-review

Original language	English
Pages (from-to)	2201-2203
Number of pages	3
Journal	Neural Regeneration Research
Volume	16
Issue number	11
DOIs	https://doi.org/10.4103/1673-5374.310684
State	Published - Nov 2021

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10.4103/1673-5374.310684

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title = "Mitofusin activation enhances mitochondrial motility and promotes neuroregeneration in CMT2A",

author = "Gerald Dorn",

note = "Funding Information: architecture ofsoma,linearaxonbody frommitochondrialdrop-outandneuronalin vitroarrangementmimicsin vivoneuronthatculminatesinmetabolic insufficiency References and distal branched axon. Because mouse death from mitochondrial pathway apoptosis. Baloh RH, Schmidt RE, Pestronk A, Milbrandt J CMT2A neurons grow very poorly (as in the According to this scenario, interrupting the (2007) Altered axonal mitochondrial transport above DRG studies), adeno-Cre was used cycle at any point could prove therapeutic. in the pathogenesis of Charcot-Marie-Tooth to induce hMFN2 T105M expression after Thus ? interventions like mitofusin activation 27:422-430.disease from mitofusin  mutations 堀 J ?eurosci the cultured cortical neurons had grown that promote general mitochondrial Chen Y, Dorn GW 2nd (2013) PINK1- through the microchannels and developed resistance to an array of noxious insults may phosphorylated mitofusin 2 is a Parkin receptor complex arborizations 縁崃堁? 堃唀in vitro). dahyas ve broad therapeutic utility 堀 for culling damaged mitochondria. Science In this way, mature CMT2A neurons were 340:471-475. created that subsequently underwent distal The present work was supported by NIH Dang X, Zhang L, Franco A, Li J, Rocha AG, aspiration axotomy, amputating the distal R HL 唀 R NS 唀 DevanaRthan S, Dolle RE, BernsNS ?tein PR, Dorn GW branched axons while leaving the proximal and Research Grant  from the 2nd (2020) Discovery of 6-phenylhexanamide linear axons intact. Amputated neurons Muscular Dystrophy Association 縁?o GWD 缃堀 derivatives as potent stereoselective mitofusin",

year = "2021",

month = nov,

doi = "10.4103/1673-5374.310684",

language = "English",

volume = "16",

pages = "2201--2203",

journal = "Neural Regeneration Research",

issn = "1673-5374",

number = "11",

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AU - Dorn, Gerald

N1 - Funding Information: architecture ofsoma,linearaxonbody frommitochondrialdrop-outandneuronalin vitroarrangementmimicsin vivoneuronthatculminatesinmetabolic insufficiency References and distal branched axon. Because mouse death from mitochondrial pathway apoptosis. Baloh RH, Schmidt RE, Pestronk A, Milbrandt J CMT2A neurons grow very poorly (as in the According to this scenario, interrupting the (2007) Altered axonal mitochondrial transport above DRG studies), adeno-Cre was used cycle at any point could prove therapeutic. in the pathogenesis of Charcot-Marie-Tooth to induce hMFN2 T105M expression after Thus ? interventions like mitofusin activation 27:422-430.disease from mitofusin  mutations 堀 J ?eurosci the cultured cortical neurons had grown that promote general mitochondrial Chen Y, Dorn GW 2nd (2013) PINK1- through the microchannels and developed resistance to an array of noxious insults may phosphorylated mitofusin 2 is a Parkin receptor complex arborizations 縁崃堁? 堃唀in vitro). dahyas ve broad therapeutic utility 堀 for culling damaged mitochondria. Science In this way, mature CMT2A neurons were 340:471-475. created that subsequently underwent distal The present work was supported by NIH Dang X, Zhang L, Franco A, Li J, Rocha AG, aspiration axotomy, amputating the distal R HL 唀 R NS 唀 DevanaRthan S, Dolle RE, BernsNS ?tein PR, Dorn GW branched axons while leaving the proximal and Research Grant  from the 2nd (2020) Discovery of 6-phenylhexanamide linear axons intact. Amputated neurons Muscular Dystrophy Association 縁?o GWD 缃堀 derivatives as potent stereoselective mitofusin

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JO - Neural Regeneration Research

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SN - 1673-5374

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ER -

Mitofusin activation enhances mitochondrial motility and promotes neuroregeneration in CMT2A

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