TY - JOUR
T1 - Mitoconfusion
T2 - Noncanonical functioning of dynamism factors in static mitochondria of the heart
AU - Song, Moshi
AU - Dorn, Gerald W.
N1 - Funding Information:
This work was supported by NIH HL59888 (G.W.D.) and an American Heart Association predoctoral fellowship award (M.S.).
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2015/2/3
Y1 - 2015/2/3
N2 - Mitochondrial fitness is central to heart health. In many cell types, mitochondria are dynamic, interconnected filamentous networks. By comparison, mitochondria of healthy postmitotic adult cardiomyocytes are shortened, round, hypodynamic organelles. Mitochondrial networks are absent in cardiomyocytes; fission, fusion, and organelle mobility are not normally observed. Nevertheless, mitochondrial fission factor Drp1 and fusion factors Mfn1, Mfn2, and Opa1 are abundant and indispensable in adult hearts. Here, we review recent insights into roles for mitochondrial dynamics factors not strictly related to morphometric remodeling, advancing the argument that fission and fusion of cardiomyocyte mitochondria support surveillance, sequestration, and mitophagic removal of damaged organelles.
AB - Mitochondrial fitness is central to heart health. In many cell types, mitochondria are dynamic, interconnected filamentous networks. By comparison, mitochondria of healthy postmitotic adult cardiomyocytes are shortened, round, hypodynamic organelles. Mitochondrial networks are absent in cardiomyocytes; fission, fusion, and organelle mobility are not normally observed. Nevertheless, mitochondrial fission factor Drp1 and fusion factors Mfn1, Mfn2, and Opa1 are abundant and indispensable in adult hearts. Here, we review recent insights into roles for mitochondrial dynamics factors not strictly related to morphometric remodeling, advancing the argument that fission and fusion of cardiomyocyte mitochondria support surveillance, sequestration, and mitophagic removal of damaged organelles.
UR - http://www.scopus.com/inward/record.url?scp=84922903805&partnerID=8YFLogxK
U2 - 10.1016/j.cmet.2014.12.019
DO - 10.1016/j.cmet.2014.12.019
M3 - Review article
C2 - 25651174
AN - SCOPUS:84922903805
SN - 1550-4131
VL - 21
SP - 195
EP - 205
JO - Cell metabolism
JF - Cell metabolism
IS - 2
ER -