Mitoconfusion: Noncanonical functioning of dynamism factors in static mitochondria of the heart

Moshi Song, Gerald W. Dorn

Research output: Contribution to journalReview articlepeer-review

74 Scopus citations

Abstract

Mitochondrial fitness is central to heart health. In many cell types, mitochondria are dynamic, interconnected filamentous networks. By comparison, mitochondria of healthy postmitotic adult cardiomyocytes are shortened, round, hypodynamic organelles. Mitochondrial networks are absent in cardiomyocytes; fission, fusion, and organelle mobility are not normally observed. Nevertheless, mitochondrial fission factor Drp1 and fusion factors Mfn1, Mfn2, and Opa1 are abundant and indispensable in adult hearts. Here, we review recent insights into roles for mitochondrial dynamics factors not strictly related to morphometric remodeling, advancing the argument that fission and fusion of cardiomyocyte mitochondria support surveillance, sequestration, and mitophagic removal of damaged organelles.

Original languageEnglish
Pages (from-to)195-205
Number of pages11
JournalCell metabolism
Volume21
Issue number2
DOIs
StatePublished - Feb 3 2015

Fingerprint Dive into the research topics of 'Mitoconfusion: Noncanonical functioning of dynamism factors in static mitochondria of the heart'. Together they form a unique fingerprint.

Cite this