Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences

Jonathan R. Brestoff

doi:10.1038/d41586-025-00077-4

Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences

Jonathan R. Brestoff

Research output: Contribution to journal › Comment/debate

5 Scopus citations

Abstract

Immune cells can destroy cancer, but tumours often evade such responses. The bidirectional transfer of mitochondria between cancer and immune cells is a newly discovered mechanism that thwarts anticancer defences.

Original language	English
Pages (from-to)	42-43
Number of pages	2
Journal	Nature
Volume	638
Issue number	8049
DOIs	https://doi.org/10.1038/d41586-025-00077-4
State	Published - Feb 6 2025

Keywords

Cancer
Immunology
Medical research

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10.1038/d41586-025-00077-4

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title = "Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences",

abstract = "Immune cells can destroy cancer, but tumours often evade such responses. The bidirectional transfer of mitochondria between cancer and immune cells is a newly discovered mechanism that thwarts anticancer defences.",

keywords = "Cancer, Immunology, Medical research",

author = "Brestoff, \{Jonathan R.\}",

note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2025.",

year = "2025",

month = feb,

day = "6",

doi = "10.1038/d41586-025-00077-4",

language = "English",

volume = "638",

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TY - JOUR

T1 - Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences

AU - Brestoff, Jonathan R.

N1 - Publisher Copyright: © Springer Nature Limited 2025.

PY - 2025/2/6

Y1 - 2025/2/6

N2 - Immune cells can destroy cancer, but tumours often evade such responses. The bidirectional transfer of mitochondria between cancer and immune cells is a newly discovered mechanism that thwarts anticancer defences.

AB - Immune cells can destroy cancer, but tumours often evade such responses. The bidirectional transfer of mitochondria between cancer and immune cells is a newly discovered mechanism that thwarts anticancer defences.

KW - Cancer

KW - Immunology

KW - Medical research

UR - https://www.scopus.com/pages/publications/85218218258

U2 - 10.1038/d41586-025-00077-4

DO - 10.1038/d41586-025-00077-4

M3 - Comment/debate

C2 - 39843696

AN - SCOPUS:85218218258

SN - 0028-0836

VL - 638

SP - 42

EP - 43

JO - Nature

JF - Nature

IS - 8049

ER -

Mitochondrial swap from cancer to immune cells thwarts anti-tumour defences

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