Mitochondrial pyruvate carrier inhibitors improve metabolic parameters in diet-induced obese mice

Keyphrases

• Metabolic Parameters 100%
• Diet-induced Obese Mice 100%
• Mitochondrial Pyruvate Carrier 100%
• Glucose Tolerance 20%
• Zaprinast 20%
• Liver 10%
• Insulin Sensitivity 10%
• Diabetes 10%
• Type 2 Diabetes Mellitus (T2DM) 10%
• Hepatocytes 10%
• Small Molecules 10%
• Glucose Production 10%
• Insulin Action 10%
• Novel Class 10%
• Obese Mice 10%
• Mouse in Vivo 10%
• Therapeutic Targeting 10%
• Hepatic Gluconeogenesis 10%
• Glucose-lowering Drugs 10%
• Respiration 10%
• Bioluminescence 10%
• Reporter Assay 10%
• Pharmacophore 10%
• Hyperinsulinemic-euglycemic Clamp 10%
• Chemical Library 10%
• Antidiabetic Effect 10%
• Resonance Energy 10%
• Intermediary Metabolism 10%
• Clamp Study 10%
• Quinolones 10%
• Nalidixic Acid 10%
• Novel Inhibitors 10%
• Inner Mitochondrial Membrane 10%
• Isolated Mitochondria 10%
• Pharmacophore Model 10%
• Quinolone Antibiotics 10%
• Membrane Complex 10%

Biochemistry, Genetics and Molecular Biology

• Mouse Mutant 100%
• Monocarboxylate Transporter 100%
• Glucose 30%
• Gluconeogenesis 20%
• Pharmacophore 20%
• Insulin Sensitivity 10%
• Metabolic Pathway 10%
• Mitochondrion 10%
• Small Molecule 10%
• Hepatocyte 10%
• Antidiabetic Activity 10%
• Inner Mitochondrial Membrane 10%
• Bioluminescence 10%
• Insulin 10%
• Maturity Onset Diabetes of the Young 10%