TY - JOUR
T1 - Mitochondrial modulation
T2 - Reversible phosphorylation takes center stage?
AU - Pagliarini, David J.
AU - Dixon, Jack E.
N1 - Funding Information:
We thank members of the Dixon laboratory for critically reading the manuscript. This work was supported by funds from the National Institutes of Health and the Walther Cancer Institute (to J.E.D.), and by National Institutes of Health Pharmacology Training Grant NIH 2 T32 GM07752–25 (to D.J.P.)
PY - 2006/1
Y1 - 2006/1
N2 - In the past 1.5 billion years, mitochondria have evolved from oxygen-scavenging bacterial symbionts into primary control centers for energy production and cellular life-and-death processes in eukaryotes. This maturation of mitochondrial function has necessitated the coevolution of various mechanisms of communication with the rest of the cell. Emerging evidence indicates that reversible phosphorylation, the most prevalent form of cellular posttranslational modification, is an important and largely overlooked means of regulating mitochondrial functions. The steadily increasing number of reported mitochondrial kinases, phosphatases and phosphoproteins suggests that phosphorylation is likely to emerge as a common theme in the regulation of mitochondrial processes.
AB - In the past 1.5 billion years, mitochondria have evolved from oxygen-scavenging bacterial symbionts into primary control centers for energy production and cellular life-and-death processes in eukaryotes. This maturation of mitochondrial function has necessitated the coevolution of various mechanisms of communication with the rest of the cell. Emerging evidence indicates that reversible phosphorylation, the most prevalent form of cellular posttranslational modification, is an important and largely overlooked means of regulating mitochondrial functions. The steadily increasing number of reported mitochondrial kinases, phosphatases and phosphoproteins suggests that phosphorylation is likely to emerge as a common theme in the regulation of mitochondrial processes.
UR - http://www.scopus.com/inward/record.url?scp=30944449043&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2005.11.005
DO - 10.1016/j.tibs.2005.11.005
M3 - Article
C2 - 16337125
AN - SCOPUS:30944449043
VL - 31
SP - 26
EP - 34
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
SN - 0968-0004
IS - 1
ER -