Mitochondrial genome linearization is a causative factor for cardiomyopathy in Mice and Drosophila

Keyphrases

• Drosophilidae 100%
• Mitochondrial DNA 100%
• Cardiomyopathy 100%
• Causal Factors 100%
• Mitofusin 2 (Mfn2) 100%
• Linearization 100%
• Cardiomyocytes 50%
• Mitochondrial Damage 37%
• Parkin 25%
• PTEN-induced Kinase 1 (PINK1) 25%
• Mfn1 25%
• Culling 25%
• RNA Sequencing (RNA-seq) 12%
• DNA Replication 12%
• Gene-deficient Mice 12%
• Specific Expression 12%
• Copy number Variation 12%
• Polymerase Chain Reaction 12%
• DNA Breaks 12%
• Mouse Heart 12%
• Quality Control 12%
• Insertion-deletion 12%
• Indel 12%
• Single nucleotide Variant 12%
• Gene Ablation 12%
• Mitochondrial Function 12%
• DNA Double-strand Breaks 12%
• Organ Dysfunction 12%
• Membranous Organelles 12%
• Southern Blot Analysis 12%
• Redox Signaling 12%
• Mitochondrial Targeting 12%
• Deletion mutation 12%
• Mitochondrial Fusion 12%
• Double Strand 12%
• Selective Deletion 12%
• Mitochondrial Outer Membrane 12%
• Parkin-mediated Mitophagy 12%
• Mitochondrial DNA Content 12%
• Mitochondrial DNA Damage 12%
• Membrane Tethering 12%
• Ultra-deep Sequencing 12%
• Mitochondrial Receptors 12%
• Organelle Fusion 12%
• Nuclear-encoded Mitochondrial Genes 12%
• Linear Mitochondrial Genome 12%

Biochemistry, Genetics and Molecular Biology

• Mitochondrial Genome 100%
• Mitochondrial DNA 100%
• Cardiac Muscle Cell 66%
• Kinase 33%
• Phosphotransferase 33%
• Mitochondrion 33%
• DNA Damage 16%
• RNA Sequence 16%
• Copy-Number Variation 16%
• Southern Blotting 16%
• Quality Control 16%
• Deep Sequencing 16%
• Indel 16%
• DNA Synthesis 16%
• Mitophagy 16%
• DNA Content 16%
• Outer Mitochondrial Membrane 16%
• Mitochondrial Gene 16%
• Mitochondrial Fusion 16%
• XhoI 16%
• Polymerase Chain Reaction 16%