Mitochondrial dysfunction in diabetic cardiomyopathy

Research output: Contribution to journalReview article

116 Scopus citations

Abstract

Cardiovascular disease is common in patients with diabetes and is a significant contributor to the high mortality rates associated with diabetes. Heart failure is common in diabetic patients, even in the absence of coronary artery disease or hypertension, an entity known as diabetic cardiomyopathy. Evidence indicates that myocardial metabolism is altered in diabetes, which likely contributes to contractile dysfunction and ventricular failure. The mitochondria are the center of metabolism, and recent data suggests that mitochondrial dysfunction may play a critical role in the pathogenesis of diabetic cardiomyopathy. This review summarizes many of the potential mechanisms that lead to mitochondrial dysfunction in the diabetic heart. This article is part of a Special Issue entitled: Mitochondria and Cardioprotection.

Original languageEnglish
Pages (from-to)1351-1359
Number of pages9
JournalBiochimica et Biophysica Acta - Molecular Cell Research
Volume1813
Issue number7
DOIs
StatePublished - Jul 1 2011

Keywords

  • Cardiomyopathy
  • Diabetes
  • Heart failure
  • Insulin resistance
  • Metabolism
  • Mitochondria
  • Oxidative stress

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