Mitochondrial Dysfunction and Autophagy in Hepatic Ischemia/Reperfusion Injury

Kristina L. Go, Sooyeon Lee, Ivan Zendejas, Kevin E. Behrns, Jae Sung Kim

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Ischemia/reperfusion (I/R) injury remains a major complication of liver resection, transplantation, and hemorrhagic shock. Although the mechanisms that contribute to hepatic I/R are complex and diverse involving the interaction of cell injury in hepatocytes, immune cells, and endothelium, mitochondrial dysfunction is a cardinal event culminating in hepatic reperfusion injury. Mitochondrial autophagy, so-called mitophagy, is a key cellular process that regulates mitochondrial homeostasis and eliminates damaged mitochondria in a timely manner. Growing evidence accumulates that I/R injury is attributed to defective mitophagy. This review aims to summarize the current understanding of autophagy and its role in hepatic I/R injury and highlight the various therapeutic approaches that have been studied to ameliorate injury.

Original languageEnglish
Article number183469
JournalBioMed Research International
Volume2015
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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