Mitochondrial dynamism and heart disease: Changing shape and shaping change

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Abstract

Mitochondria of adult cardiomyocytes appear hypo-dynamic, lacking interconnected reticular networks and the continual fission and fusion observed in many other cell types. Nevertheless, proteins essential to mitochondrial network remodeling are abundant in adult hearts. Recent findings from cardiac-specific ablation of mitochondrial fission and fusion protein genes have revealed unexpected roles for mitochondrial dynamics factors in mitophagic mitochondrial quality control. This overview examines the clinical and experimental evidence for and against a meaningful role for the mitochondrial dynamism-quality control interactome in normal and diseased hearts. Newly discovered functions of mitochondrial dynamics factors in maintaining optimal cardiac mitochondrial fitness suggest that deep interrogation of clinical cardiomyopathy is likely to reveal genetic variants that cause or modify cardiac disease through their effects on mitochondrial fission, fusion, and mitophagy.

Original languageEnglish
Pages (from-to)865-877
Number of pages13
JournalEMBO Molecular Medicine
Volume7
Issue number7
DOIs
StatePublished - Jul 1 2015

Keywords

  • Cardiomyopathy
  • Mitochondrial fission
  • Mitochondrial fusion
  • Mitophagy
  • Parkinson's disease

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