350 Scopus citations


The mitochondrion is a complex organelle that serves essential roles in energy transduction, ATP production, and a myriad of cellular signaling events. A finely tuned regulatory network orchestrates the biogenesis, maintenance, and turnover of mitochondria. The high-capacity mitochondrial system in the heart is regulated in a dynamic way to generate and consume enormous amounts of ATP in order to support the constant pumping function in the context of changing energy demands. This review describes the regulatory circuitry and downstream events involved in mitochondrial biogenesis and its coordination with mitochondrial dynamics in developing and diseased hearts.

Original languageEnglish
Pages (from-to)1981-1991
Number of pages11
JournalGenes and Development
Issue number19
StatePublished - Oct 1 2015


  • Biogenesis
  • Mitochondria
  • Mitochondrial dynamics
  • Mitophagy


Dive into the research topics of 'Mitochondrial biogenesis and dynamics in the developing and diseased heart'. Together they form a unique fingerprint.

Cite this