Mitochondrial biogenesis and dynamics in the developing and diseased heart

Gerald W. Dorn, Rick B. Vega, Daniel P. Kelly

Research output: Contribution to journalReview articlepeer-review

197 Scopus citations

Abstract

The mitochondrion is a complex organelle that serves essential roles in energy transduction, ATP production, and a myriad of cellular signaling events. A finely tuned regulatory network orchestrates the biogenesis, maintenance, and turnover of mitochondria. The high-capacity mitochondrial system in the heart is regulated in a dynamic way to generate and consume enormous amounts of ATP in order to support the constant pumping function in the context of changing energy demands. This review describes the regulatory circuitry and downstream events involved in mitochondrial biogenesis and its coordination with mitochondrial dynamics in developing and diseased hearts.

Original languageEnglish
Pages (from-to)1981-1991
Number of pages11
JournalGenes and Development
Volume29
Issue number19
DOIs
StatePublished - Oct 1 2015

Keywords

  • Biogenesis
  • Mitochondria
  • Mitochondrial dynamics
  • Mitophagy

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