TY - JOUR
T1 - Mitochondria in Neuronal Health
T2 - From Energy Metabolism to Parkinson's Disease
AU - Murali Mahadevan, Hariharan
AU - Hashemiaghdam, Arsalan
AU - Ashrafi, Ghazaleh
AU - Harbauer, Angelika Bettina
N1 - Publisher Copyright:
© 2021 The Authors. Advanced Biology published by Wiley-VCH GmbH
PY - 2021/9
Y1 - 2021/9
N2 - Mitochondria are the main suppliers of neuronal adenosine triphosphate and play a critical role in brain energy metabolism. Mitochondria also serve as Ca2+ sinks and anabolic factories and are therefore essential for neuronal function and survival. Dysregulation of neuronal bioenergetics is increasingly implicated in neurodegenerative disorders, particularly Parkinson's disease. This review describes the role of mitochondria in energy metabolism under resting conditions and during synaptic transmission, and presents evidence for the contribution of neuronal mitochondrial dysfunction to Parkinson's disease.
AB - Mitochondria are the main suppliers of neuronal adenosine triphosphate and play a critical role in brain energy metabolism. Mitochondria also serve as Ca2+ sinks and anabolic factories and are therefore essential for neuronal function and survival. Dysregulation of neuronal bioenergetics is increasingly implicated in neurodegenerative disorders, particularly Parkinson's disease. This review describes the role of mitochondria in energy metabolism under resting conditions and during synaptic transmission, and presents evidence for the contribution of neuronal mitochondrial dysfunction to Parkinson's disease.
KW - OXPHOS
KW - glycolysis
KW - neurodegeneration
KW - synaptic transmission
UR - http://www.scopus.com/inward/record.url?scp=85112271810&partnerID=8YFLogxK
U2 - 10.1002/adbi.202100663
DO - 10.1002/adbi.202100663
M3 - Review article
C2 - 34382382
AN - SCOPUS:85112271810
SN - 2701-0198
VL - 5
JO - Advanced Biology
JF - Advanced Biology
IS - 9
M1 - 2100663
ER -