Missense VKOR mutants exhibit severe warfarin resistance but lack VKCFD via shifting to an aberrantly reduced state

Keyphrases

• Missense 100%
• Vitamin K Epoxide Reductase 100%
• Reduced State 100%
• Warfarin Resistance 100%
• VKCFD1 100%
• Active Sites 33%
• Warfarin 33%
• Molecular Dynamics Simulation 16%
• Small Molecules 16%
• Mass Spectrometry 16%
• Increased Activity 16%
• Abnormal Bleeding 16%
• Footprinting 16%
• Protein Conformation 16%
• Substrate Binding 16%
• Simulation-based 16%
• Resistance mutations 16%
• Redox State 16%
• Reductase Activity 16%
• Constitutive Behavior 16%
• Resistant mutation 16%
• Anticoagulation Strategy 16%
• Artificial Opening 16%
• CRISTAL 16%
• Warfarin Treatment 16%
• Mutation Change 16%

Biochemistry, Genetics and Molecular Biology

• Missense 100%
• Vitamin K Epoxide Reductase 100%
• Active Site 33%
• Crystal Structure 16%
• Mass Spectrometry 16%
• Small Molecule 16%
• Protein Conformation 16%
• Anticoagulation 16%