Missense Mutations in Myc Box I Influence Nucleocytoplasmic Transport to Promote Leukemogenesis

Keyphrases

• Acute Myeloid Leukemia 100%
• Leukemogenesis 100%
• Missense mutation 100%
• Nucleocytoplasmic Transport 100%
• Hematopoietic Cells 66%
• Knock-in Mouse Model 66%
• MYC Protein 66%
• Germ Cells 33%
• Self-renewal 33%
• Overexpression 33%
• Hematological Malignancies 33%
• Mutant Protein 33%
• Cell Death 33%
• Bone Marrow 33%
• Threonine 33%
• Mutant Phenotype 33%
• RNA-binding Protein 33%
• Progenitor Cells 33%
• Mutant Cells 33%
• Proline 33%
• Nuclear Export 33%
• Transcriptome 33%
• MiRNA Profile 33%
• Omics Approaches 33%
• Transcriptional Signature 33%
• MYC Gene 33%
• Molecular Consequences 33%
• Immune-related Genes 33%
• Pro-apoptotic 33%
• Nucleoplasm 33%
• Transport Mechanism 33%
• Cell Surface Display 33%
• Protein Import 33%
• Hematopoietic Tumors 33%
• Progenitor Expansion 33%
• Phenotype Features 33%
• Phosphodegron 33%

Biochemistry, Genetics and Molecular Biology

• Wild Type 100%
• Myeloid 100%
• Nuclear Transport 100%
• Missense Mutation 100%
• Myc 100%
• RNA 66%
• Hematopoietic Cell 66%
• Germline 33%
• Germ Cell 33%
• Mutant Protein 33%
• Cell Death 33%
• Progenitor Cell 33%
• RNA-binding Protein 33%
• Cell Mutant 33%
• Nuclear Export 33%
• Locus Control Region 33%
• Immunity 33%
• Oncogene Myc 33%
• Tamsulosin 33%
• Threonine 33%
• Proline 33%
• Transcriptome 33%