Abstract
The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.
| Original language | English |
|---|---|
| Pages (from-to) | 1396-1397 |
| Number of pages | 2 |
| Journal | Neurology |
| Volume | 55 |
| Issue number | 9 |
| DOIs | |
| State | Published - Nov 14 2000 |
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