Misleading results with the 14-3-3 assay for the diagnosis of Creutzfeldt-Jakob disease

T. Chapman, D. W. McKeel, John C. Morris

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

The definitive diagnosis of Creutzfeldt-Jakob disease (CJD) requires brain tissue analysis. A positive assay for the 14-3-3 protein in CSF has been suggested to be highly sensitive and specific in patients with CJD. The authors describe three patients for whom CSF 14-3-3 assays were falsely positive or falsely negative. Caution against overreliance on this putative biomarker is suggested in the diagnosis of CJD.

Original languageEnglish
Pages (from-to)1396-1397
Number of pages2
JournalNeurology
Volume55
Issue number9
DOIs
StatePublished - Nov 14 2000

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